依托咪酯靶控输注在老年患者无痛肠镜中的安全性评价  

Safety evaluation of etomidate target controlled infusion in indolent enteroscope among senior patients

作　　者：杨佳宁 赵国庆[1] 李龙云[1] 苏振波[1] 

机构地区：[1]吉林大学中日联医院麻醉科,吉林长春130033

出　　处：《中国实验诊断学》2017年第10期1753-1755,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨依托咪酯靶控输注应用在拟行肠镜检查的老年患者的可行性。方法选择100例年龄65-75岁于我院行无痛肠镜检查的老年患者,采用随机数字表法分为E组(靶控输注依托咪酯组)和P组(靶控输注丙泊酚组),每组各50例。观察并记录两组靶控输注麻醉药物开始前即刻(T1),入镜即刻(T2),入镜3 min(T3),苏醒时(T4)的平均动脉压,心率,血氧饱和度,诱导时间,肠镜操作时间,不良反应,苏醒时间(停药至呼之睁眼时间),苏醒后15min的Steward评分。结果 P组T2,T3时间点的平均动脉压、心率明显低于E组,E组的不良反应除肌阵挛外均少于P组,差异均有统计学意义(P<0.05)。两组的诱导时间,检查时间,苏醒时间,苏醒后15min Steward评分的差异均无统计学意义(P>0.05)。结论芬太尼复合依托咪酯靶控输注用于老年患者无痛结肠镜检查的麻醉可使血流动力学更稳定,呼吸抑制更轻,不良反应发生率较少,值得临床推广。Objective To investigate the feasibility of etomidate target controlled infusion（TCI）among senior patients with enteroscope examination schedule.Methods A total of 100 senior patients（65-75 years old）receiving indolent enteroscope at our hospital were evenly divided into E group（etomidate TCI）and P group（propofol TCI）by random number table method.Then mean arterial pressure,heart rate,oxyhemoglobin saturationat starting infusion（T1）,inserting enteroscope（T2）,3min after inserting（T3）and awakening（T4）were observed and recorded.And induction time,enteroscope manipulation duration,adverse reaction,awakening time（drug withdrawal to eyes opening）and Steward scoring of 15 min after awakening in two groups were also observed and recorded.Results Mean arterial pressure and heart rate of T2,T3 in P group were significantly lower than E group,and adverse reaction excluding myoclonus in E group were all lower than P group,where the differences were statistically significant（P〈0.05）.No statistical significance in induction time,examination duration,awakening time and Steward scoring of 15 min after awakening was found between two groups（P〉0.05）.Conclusion The application of fentanyl with etomidate TCI in indolent enteroscope among senior patients leads to more stable haemodynamics,less respiratory depression and lower incidence of adverse reaction,which is worthy of clinical promotion.

关 键 词：老年人 无痛肠镜 靶控输注 依托咪酯 

分 类 号：R614[医药卫生—麻醉学]