双氯芬酸钠缓释胶囊释放度及兔体内生物利用度测定  

Studies on release rates and bioavailability of diclofenac sodium sustained release capsules in rabbits

作　　者：林宁[1] 肖学成[1] 饶泽萍[1] 丁广林[1] 

机构地区：[1]湖北药检高等专科学校,湖北武汉430064

出　　处：《西北药学杂志》2002年第4期165-167,共3页Northwest Pharmaceutical Journal

摘　　要：目的　制备双氯芬酸钠缓释胶囊 (DS- SRC) ,并对其释放度与生物利用度进行研究。方法　通过测定 DS-SRC的释放度 ,进行释放机制的研究 ;并测定了家兔体内血药浓度 ,研究 DS- SRC的相对生物利用度。结果　DS- SRC体外释放曲线符合 Higuchi方程 ;该制剂相对于普通片剂释药稳定、生物利用度高。结论　体内外试验表明 DS-Objective Diclofenac sodium sustained release capsules(DS-SRC) were prepared. The release rate and bioavailability of DS-SRC were studied. MethodTo study release mechanism by determining dissolution rate and study relative bioavailability of DS-SRC by determining serum diclofenac sodium concentrations in rabbits. Results The release profile of DS-SRC followed Higuchi kinetics. This kind of sustained release preparation has some outstanding characteristics compare with generic tablets, such as release stability and high bioavailability. Conclusion DS-SRC showed an obvious sustained release effect.

关 键 词：双氯芬酸钠 缓释胶囊 释放度 生物利用度 

分 类 号：R945[医药卫生—微生物与生化药学]