甲基茉莉醛的合成工艺研究  

Study on the Synthesis of 2-(4-methylphenyl) Methylene-heptaldehyde

作　　者：刘镇升 丘乐意 温华健 梁耀涵 张红 Liu Zhensheng Qiu Leyi Wen Huajian Liang Yaohan Zhang Hong(Guangdong Pharmaceutical University, College of Medicine and Chemical Engineering, Zhongshan 528458 Guangdong Cosmetic Engineering Technology Research Center, Guangzhou 510006, China)

机构地区：[1]广东药科大学医药化工学院,广东中山528458 [2]广东省化妆品工程技术研究中心,广东广州510006

出　　处：《广东化工》2017年第20期10-12,共3页Guangdong Chemical Industry

摘　　要：本文以对甲基苯甲醛与正庚醛为原料,在碱和相转移催化剂作用下经羟醛缩合反应水相中合成香料甲基茉莉醛。用正交试验法对甲基茉莉醛的合成工艺进行优选,最后得到合成甲基茉莉醛的较优工艺:对甲基苯甲醛与正庚醛的投料摩尔比为1.4︰1.0,相转移催化剂苄基三乙基氯化铵用量为正庚醛摩尔数的6%,缓慢滴加正庚醛,控制反应温度65℃,反应5 h,在此较佳条件下甲基茉莉醛的收率约为77.3%。The Synthesis technology of 2-（4-methylphenyl）methylene-heptaldehyde was mainly discussed in this paper that was an aldol condensation of p-methylbenzaldehyde and n-heptylaldehyde under phase transfer catalysis in the aqueous phase. The optimal reaction conditions determined by orthogonal experiment are as follows： when heptylaldehyde is 6.84 g （0.06 mol）, the reactant molar ratio of p-methylbenzaldehyde to heptylaldehyde is 1.4 to 1, the amount of BTEAC is 6 % of n-heptylaldehyde, reaction temperature is 65 ℃, reaction time is 5 hours, the yield is about 77.3 %.

关 键 词：甲基茉莉醛 相转移催化 羟醛缩合 正交试验 

分 类 号：TQ463.4[化学工程—制药化工]