脂蛋白相关磷脂酶A2与系统性红斑狼疮相关性研究  

Study on the Relationship Between Lipoprotein-related Phospholipase A2 and Systemic Lupus Erythematosus

作　　者：王坤[1] 贾兴旺[1] 董矜[1] 颜光涛[1] 

机构地区：[1]解放军总医院生化科,北京100853

出　　处：《标记免疫分析与临床》2017年第10期1081-1084,1090,共5页Labeled Immunoassays and Clinical Medicine

基　　金：国家科技支撑计划(2015BAK45B01)

摘　　要：目的探讨脂蛋白相关磷脂酶A2与系统性红斑狼疮病情进展的相关性。方法收集177例我院确诊的SLE患者与60例年龄性别匹配的健康人员血清标本,检测标本LP-PLA2的活性水平以及其他相关指标,根据疾病的不同活动程度以及不同并发症对患者进行分组,比较组间LP-PLA2的差异性。采用多重线性回归分析建模探讨LP-PLA2与其他指标的关联。结果病情处于活动期的SLE患者和肾脏受累、贫血以及血凝异常组具有更高活性水平的LP-PLA2;LP-PLA2与LDL、SLEDAI评分、ALB、GLU和AST呈正相关,与HDL呈负相关。结论 LP-PLA2的活性水平与SLE患者的病情活动程度相关,并且可以用来评估SLE患者并发症的进展情况。Abstract：Objective To investigate the correlation between lipoprotein-associated phospholipase A2 and progression of systemic lupus erythematosus. Methods A total of 177 SLE patients diagnosed in our hospital were randomly divided into two groups. The serum levels of LP-PLA2 and other related indexes were measured. The patients were divided according to the different activities of the disease and the different complications. We then compared the LP-PLA2 differences between groups. The relationship between LP-PLA2 and other indexes was explored by multiple linear regression analysis. Results The patients with active SLE and kidney involvement, anemia and hemagglutination abnormalities had higher activity levels of LP-PLA2; LP-PLA2 was positively correlated with LDL, SLEDAI score, ALB, GLU and AST, and was negatively correlated with HDL. Conclusion The activity level of LP-PLA2 is associated with the severity of SLE patients and can be used to assess the progression of complications in patients with SLE.

关 键 词：脂蛋白相关磷脂酶A2 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]