小肝细胞癌超声声像图与射频消融预后关系研究  

Study on correlation between ultrasonography and prognosis of radiofrequency ablation in SHCC

作　　者：吴汤娜[1] 符少清[1] 刘秉彦[1] 

机构地区：[1]海南省人民医院超声科,海南海口570311

出　　处：《中国现代医学杂志》2017年第24期70-74,共5页China Journal of Modern Medicine

摘　　要：目的研究小肝细胞癌(SHCC)B超分类与射频消融(RFA)预后相关性。方法回顾性分析2006年1月-2010年12月在该院接受RFA治疗的SHCC患者97例。根据超声影像图,将患者分为两类:1型,有晕征(n=29);2型,无晕征(n=68)。2型进一步分为3个亚型:2a型,均匀高回声(n=9);2b型,低回声,边缘平滑(n=43);2c型(n=16),低回声,边缘不规则或不清晰。由于病例数量小,该研究将2a型SHCC患者排除在外。结果 2b型、1型和2c型患者2年复发率分别为26%、42%和69%,2b型和2c型(P=0.008),以及1型和2c型(P=0.005)差异有统计学意义。2b型、1型和2c型患者5年生存率分别为89%、43%和65%。2b型生存时间长于其他类型(P_(1型和2b型)=0.009;P_(2b型和2c型)=0.008)。多因素分析表明B超分型是与无复发生存率(P=0.027)和生存(P=0.003)均独立相关的变量。结论 SHCC B超分型是RFA预后的预测因子。Objective To study the correlation between ultrasonography and prognosis of radiofrequency ab-lation （RFA） in hepatocellular car cinoma （SHCC）. Methods A total of 97 cases of SHCC with RFA were included in a retrospective analysis from January 2006 to December 2010. Patients were divided into 2 types according to ultrasound images： type 1, with halo sign （ n=29）; type 2, without halo sigh （ n=68）. Type 2 was further categorized into three subgroups： type 2a, homogenous hyperecho （ n= 9）; type 2b, hypoecho with smooth margins （ n=43）; and type 2c （ n=16）, hypoecho with irregular or unclear margins. Patients with type 2a SHCC were excluded due to the small number of cases. Results Two-year recurrence rates for type 2b, type 1 and type 2c were 26%, 42% and 69%, respectively, with significant differences between type 2b and type 2c （ P=0.008）, and between type 1 and type 2c （ P=0.005）. Five-year survival rates were 89%, 43% and 65%, respectively. Survival time of type 2b was significantly longer than that of other types （type 1 vs type 2b, P=0.009; type 2b vs type 2c,P =0.008）. Multivariate analysis identified that ultrasound classification was independent of recurrence （P =0.027） and survival （ P=0.003）. Conclusion B-mode ultrasound classification of SHCC is a predictive factor of prognosis of RFA.

关 键 词：B型超声 肝细胞癌 射频消融 复发 预后 

分 类 号：R735.7[医药卫生—肿瘤]