肺泡微结石症的临床诊治和文献复习  

Clinical analysis of pulmonary alveolar microlithiasis and review of literature

作　　者：罗凌[1] 赵媛 韦彩周[1] 刘航[1] 

机构地区：[1]广西壮族自治区人民医院呼吸内科,南宁530021

出　　处：《中国临床新医学》2017年第10期957-960,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西卫计委科研课题(编号:Z2015676)

摘　　要：目的提高肺泡微结石症(PAM)的诊治水平。方法对收治的2例PAM的临床和病理诊断进行分析总结和文献复习。结果患者1活动后呼吸困难2个月,入院时已出现肺源性心脏病表现,肺部CT提示双肺弥漫性密度增高及钙化表现。患者2无明显症状,但经支气管肺活检(transbronchial lung biopsy,TBLB)组织病理学发现肺泡腔内及间隔有大量钙化小体,并且其肺部CT也提示两肺弥漫钙化影。2例患者最终均诊断为PAM。结论 PAM临床表现缺乏特征性,典型的临床影像学和经支气管肺病理活检表现有助于诊断。目前PAM尚无有效的治疗方法。Objective To improve the diagnosis and treatment of pulmonary alveolar microlithiasis（PAM）.Methods The clinical manifestations and radiological and pathological characteristics of PAM in two patients were analyzed and the related literatures were reviewed.Results One of the two patients presenting with progressive shortness of breath on exertion for two months was admitted to our hospital with clinical presentation of pulmonary heart disease. A chest computed tomography（CT） scan showed typical features with multiple bilateral diffuse calcifications. The other patient showed no obvious symptoms, but transbronchial lung biopsy（TBLB） showed numerous calcified bodies in the alveolar spaces and CT scan showed multiple bilateral diffuse calcifications. Based on the aforementioned observations, the two patients were diagnosed with PAM.Conclusion The clinical presentation of PAM is non-specific. The typical radiological features and the pathological characteristics are helpful for diagnosis of PAM.

关 键 词：肺泡微结石症 预计值 肺弥漫性 肺功能检查 弥散功能 肺泡腔 小叶间隔 文献复习 尼可地尔 SGK 胸膜增厚 肺源性心脏病 脏层胸膜 肺实质 临床诊治 

分 类 号：R56[医药卫生—呼吸系统]