子痫前期患者血栓前状态的简易监测及低分子肝素治疗研究  

Simple Monitoring of Prethrombotic State in Pre Eclampsia Patients and Study of Low Molecular Weight Heparin Therapy

作　　者：李晓东[1] 郑艳辉[1] 吴芹[1] 汪燕[1] 

机构地区：[1]厦门大学附属第一医院妇产科,福建厦门361002

出　　处：《中国卫生标准管理》2017年第22期23-25,共3页China Health Standard Management

摘　　要：目的通过对子痫前期患者临床数据监测,建立子痫前期患者血栓前状态的简易监测,通过低分子肝素治疗,研究治疗效果。方法本研究以75例子痫前期患者为研究对象,通过临床凝血五项及血常规常规化验监测子痫前期凝血状态的变化,并用低分子肝素进行治疗,达到预期治疗的目的。结果子痫前期重度组与正常妊娠组比较,FIB、D-二聚体水平高于正常妊娠组,PT水平低于正常妊娠组;WBC、RBC、Hb、HCT、PLT增高率,高于正常妊娠组(P<0.05);子痫前期重度患者经小剂量肝素治疗后D-二聚体和治疗前比较差异具有统计学意义。结论通过监测血常规及凝血指标的变化,对病情的发展,对血栓前状态作出早期监测,诊断及处置,对疾病预后有较好的临床价值。Objective By monitoring the clinical data of patients with preeclampsia, a simplified monitoring of prethrombotic state in pre eclampsia was established, and the therapeutic effect was studied by low molecular heparin treatment. Methods In this study, 75 patients with preeclampsia were selected as the research object, through the change of clinical blood coagulation fve and blood routine tests of monitoring blood coagulation status in preeclampsia, and with low molecular weight heparin treatment, to achieve the desired therapeutic goal. Results The results of the study showed that in severe preeclampsia group and normal pregnancy group, FIB, DD levels were higher than the normal pregnancy group, the PT level was lower than the normal pregnancy group; WBC, RBC, Hb, HCT and PLT increased rate was signifcantly higher than that in normal pregnancy group （P 〈 0.05）; there was significant difference in severe preeclampsia patients with low dose heparin D-dimer after treatment and before treatment. Conclusion By monitoring the changes of blood routine and coagulation indexes, the early diagnosis, diagnosis and treatment of the condition of thrombosis and the pre thrombosis status are of good clinical value.

关 键 词：子痫前期 监测 低分子肝素 

分 类 号：R714[医药卫生—妇产科学]