高效液相色谱法测定谷胱甘肽含片与片剂人体药代动力学  

Determination and pharmacokinetics of Glutathione Buccal Tablets tablet by HPLC

作　　者：陈志霖 赵雷 王瑶 

机构地区：[1]华中科技大学同济医学院附属协和医院感染科,湖北武汉430022

出　　处：《中国生化药物杂志》2017年第10期29-31,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探究谷胱甘肽含片与片剂的药代动力学差异。方法选20名志愿者接受药代动力学临床实验,采用单剂量平行交叉给药方式,经高效液相色谱法测定血浆药物浓度—时间参数,对药代动力学进行评价。结果受检者服药后0.25～5 h期间相同时间点两种剂型组的血药浓度差异具有统计学意义（P〈0.05）,GSH含片的药物稳定性优于GSH片剂（P〈0.05）。GSH含片分布半衰期（t1/2）1.56 h,显著低于GSH片剂（P〈0.05）。GSH含片谷胱甘肽浓度达峰时间（tmax）1.75 h,显著高于GSH片剂（P〈0.05）,GSH含片谷胱甘肽浓度峰值（Cmax）11.077,显著高于GSH片剂（P〈0.05）。结论 GSH含片的血药峰浓度更高,到达峰浓度的时间长,作用时间更长久,GSH含片的药代动力学明显优于GSH片剂。Objective To explore the differences in the pharmacokinetics of Glutathione Buccal Tablets and tablets.Methods 20 volunteers received pharmacokinetic experiments,using single dose crossover parallel mode of administration,the HPLC method for the determination of plasma concentration time parameters to evaluate the pharmacokinetics.Results The difference was statistically significant the blood concentration of subjects after taking 0.25 to 5 h during the same time point of two forms of group,GSH tablet drug stability is better than that of GSH（P〈0.05）.GSH tablets into tablets Cloth（t1/2） 1.56 h,the half-life was significantly lower than that of GSH（P〈0.05）.GSH tablets tablets glutathione concentration peak time（tmax） of 1.75 h was significantly higher than that of GSH（P〈0.05） GSH tablets,tablets of glutathione concentration peak（Cmax） of 11.077,significantly higher than that of GSH tablets（P〈0.05）.Conclusion The peak plasma concentration of GSH tablets higher.Reach the peak concentration time and time longer,the pharmacokinetics of GSH tablets is better than that of GSH tablet,which has broad application prospect.

关 键 词：高效液相色谱法 药代动力学 生物利用度 谷胱甘肽含片 谷胱甘肽片剂 

分 类 号：R965[医药卫生—药理学]