超临界流体快速膨胀过程制备药物微粒的研究进展  

Research progress on preparation of drug microparticles by rapid expansion of supercritical solution

作　　者：查贤君 王秀东[1] 焦真[1,2] ZHA Xian-jun WANG Xiu-dong JIAO Zhen(School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China Suzhou Joint Research Institute of Southeast University and Monash University, Suzhou 215123, China)

机构地区：[1]东南大学化学化工学院,江苏南京211189 [2]东南大学-蒙纳士大学苏州联合研究院,江苏苏州215123

出　　处：《现代化工》2017年第10期34-38,共5页Modern Chemical Industry

基　　金：江苏省自然科学基金项目(BK20130602);苏州纳米科技协同创新中心项目;江苏高校优势学科建设工程项目

摘　　要：介绍了RESS过程的原理及其在制备药物微粒方面的应用,重点综述了操作过程中的温度、压力、喷嘴结构、喷射距离、助溶剂及产品收集环境等参数对制得粒子形貌的影响,讨论了近年来RESS过程制备药物微粒的新进展。此外,还分析了RESS过程在实用中仍存在的一些问题,并展望了今后的研究方向。This paper introduces the principle of rapid expansion of supercritical solution（RESS） and its application in the preparation of drug microparticles. The influences of temperature,pressure,structure of the nozzle,spraying distance,co-solvent and product collection environment on particle ＇s morphology prepared are summarized emphatically.The development and new progress on the preparation of drug microparticles using RESS in recent years are discussed.In addition,the problems existed in the practical use of RESS are analyzed and the future research direction is expected.

关 键 词：超临界流体快速膨胀过程 制粒 粒径 影响因素 

分 类 号：TQ021[化学工程]