Effects and mechanisms of Bacillus thuringiensis crystal toxins for mosquito larvae  

作　　者：Qi Zhang Gang Hua Michael J. Adang 

机构地区：[1]College of Plant Protection, Shenyang Agricultural University, Shenyang, China [2]Department of Entomology, University of Georgia,Athens, GA, USA [3]Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA, USA

出　　处：《Insect Science》2017年第5期714-729,共16页昆虫科学（英文版）

摘　　要：Bacillus thuringiensis is a Gram-positive aerobic bacterium that produces insecticidal crystalline inclusions during sporulation phases of the mother cell. The vir- ulence factor, known as parasporal crystals, is composed of Cry and Cyt toxins. Most Cry toxins display a common 3-domain topology. Cry toxins exert intoxication through toxin activation, receptor binding and pore formation in a suitable larval gut environment. The mosquitocidal toxins of Bt subsp, israelensis （Bti） were found to be highly active against mosquito larvae and are widely used for vector control. Bt subsp, jegathesan is another strain which possesses high potency against broad range of mosquito larvae. The present review summarizes characterized receptors for Cry toxins in mosquito larvae, and will also discuss the diversity and effects of 3-D mosquitocidal Cry toxin and the ongo- ing research for Cry toxin mechanisms generated from investigations of lepidopteran and dipteran larvae.Bacillus thuringiensis is a Gram-positive aerobic bacterium that produces insecticidal crystalline inclusions during sporulation phases of the mother cell. The vir- ulence factor, known as parasporal crystals, is composed of Cry and Cyt toxins. Most Cry toxins display a common 3-domain topology. Cry toxins exert intoxication through toxin activation, receptor binding and pore formation in a suitable larval gut environment. The mosquitocidal toxins of Bt subsp, israelensis （Bti） were found to be highly active against mosquito larvae and are widely used for vector control. Bt subsp, jegathesan is another strain which possesses high potency against broad range of mosquito larvae. The present review summarizes characterized receptors for Cry toxins in mosquito larvae, and will also discuss the diversity and effects of 3-D mosquitocidal Cry toxin and the ongo- ing research for Cry toxin mechanisms generated from investigations of lepidopteran and dipteran larvae.

关 键 词：Bacillus thuringiensis Cry toxins mode of action MOSQUITO RECEPTORS 

分 类 号：S476.11[农业科学—农业昆虫与害虫防治] TQ453.2[农业科学—植物保护]