江苏地区汉族人群23个Y染色体STR基因座的多态性  

Polymorphisms of 23 Y-chromosome STR Loci in A Han Population in Jiangsu Province

作　　者：马骏[1] 朱爱华[1] 石津玮 金明[1] 巴华杰[1] 平智广[2] 

机构地区：[1]江苏省常州市公安局物证鉴定所,江苏常州213003 [2]郑州大学公共卫生学院卫生统计学教研室,郑州450001

出　　处：《中国医学科学院学报》2017年第5期631-639,共9页Acta Academiae Medicinae Sinicae

摘　　要：目的调查23个Y染色体STR基因座在江苏汉族人群中的多态性分布。方法采用Power Plex Y23荧光标记复合扩增系统,对江苏地区4821名汉族无关男性个体的静脉血DNA进行复合扩增,3500x L遗传分析仪进行毛细管电泳检测,分别计算各个STR基因座的等位基因频率和基因多样性,以及23个基因座联合构成的单倍型频率和单倍型多样性。结果 23个Y染色体STR基因座在4821名江苏汉族男性个体中的基因多样性值介于0.4099~0.9696。共检出4781种不同的单倍型,其中有4743种只出现1次,单倍型多样性达到0.99999812。结论 23个Y染色体STR基因座联合应用于江苏地区汉族人群时具有较好的遗传多态性分布,适用于该地区的群体遗传学与法医学个体识别等研究。Objective To investigate the polymorphisms of 23 Y-STR loci in a Han population in Jiangsu province. Methods Blood samples were collected from 4821 unrelated healthy Han males in Jiangsu province. DNA templates were amplified by Power Plex Y23 kit, and the amplification products were detected by3500 x L genetic analyzer. Then,we calculated the allele frequencies and gene diversities respectively,as well as the haplotype frequencies and haplotype diversities. Results The gene diversity of these 23 Y-STR loci ranged0. 4099-0. 9696. A total of 4781 haplotypes were detected,of which 4743 were found once. The haplotype diversity was 0. 99999812. Conclusion The 23 Y-STR loci used in this study are highly polymorphic in Han individuals in Jiangsu province and therefore suitable for population genetic study and forensic individual identification.

关 键 词：Y染色体 短串联重复序列 遗传多态性 

分 类 号：Q347[生物学—遗传学]