多功能电离子联合干扰素与咪喹莫特治疗肛周尖锐湿疣疗效分析  

Analysis of multi-function electric ions combined interferon and imiquimod in treatment of peranal condyloma acuminatum

作　　者：彭刚[1] 彭乙华[2] 蔡燕[3] 牟韵竹[4] 

机构地区：[1]岳池县人民医院皮肤科,四川岳池638300 [2]川北医学院附属医院内分泌科 [3]川北医学院附属医院检验科 [4]川北医学院附属医院皮肤科,四川南充637000

出　　处：《川北医学院学报》2017年第5期715-717,724,共4页Journal of North Sichuan Medical College

基　　金：南充市科技计划项目(N2009-ZC009)

摘　　要：目的:探讨多功能电离子联合干扰素与咪喹莫特治疗肛周尖锐湿疣的临床效果。方法:收集初发肛周尖锐湿疣病患150例,随机分为3组:电离子与干扰素组(干扰素组)、电离子与咪喹莫特组(咪喹莫特组)以及电离子联合干扰素与咪喹莫特组(联合组),观察分析3组患者的治疗效果。结果:治疗后联合组总有效率(98.0%),显著高于干扰素组(88.0%)或者咪喹莫特组(84.0%);联合组复发率为18.0%,显著低于干扰素组(52.0%)或者咪喹莫特组(48.0%);联合组平均复发时间为(74.3±5.9)d,显著高于干扰素组(26.7±5.2)d或咪喹莫特组(25.9±7.1)d,联合组的总有效率、复发率和复发时间与其它两组进行比较,差异均有统计学意义(P<0.05)。3组患者治疗后3个月不良反应总发生率比较无统计学意义(P>0.05)。结论:多功能电离子联合干扰素与咪喹莫特治疗肛周尖锐湿疣复发率低,疗效好,值得临床推广使用。Objective：To investigate the clinical effect of multi-function electric ions combined interferon and imiquimod in the peranal condyloma acuminatum.Methods：150 cases of primary peranal condyloma acuminatum patients diagnosed were collected,randomly be divided into 3 groups,interferon group （ions combined interferon）,（imiquimod group）,（ions combined imiquimod）,（combination group）,（ions combined interferon and imiquimod）.Results：The total efficiency of the combination group was 98%,obviously higher than that of the interferon group （88%） or the imiquimod group （84%）.Tthe recurrence rate of the combination group was18%,lower than that of the interferon group （52%） or the imiquimod group （48%）.The average recurrence time of the combination group was （74.3 ± 5.9） days,longer than that of the interferon group （26.7 ± 5.2） days or the imiquimod group （25.9 ± 7.1） days,there were statistically significant differences when compared the combination group with the imiquimod group or the interferon group （P〈0.05）,while there were no difference of the incidence of total adverse reactions among these groups （P〈0.05）.Conclusion：The treatment of multi function electric ion combined with interferon and imiquimod in peranal condyloma acuminatum has good curative effect,low recurrence rate,worthy of clinical application.

关 键 词：多功能电离子 干扰素 咪喹莫特 肛周尖锐湿疣 联合治疗 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]