多甲氧基黄酮抗肿瘤作用研究进展  

The research progress of anti-tumor effect of polymethoxyflavonoids

作　　者：陈圣敏 董杨 

机构地区：[1]上海中医药大学教学实验中心,上海201203

出　　处：《中国药理学通报》2017年第11期1493-1495,共3页Chinese Pharmacological Bulletin

基　　金：上海市教委重点学科资助项目(No J50301)

摘　　要：肿瘤是死亡率很高的一种疾病,严重威胁人类的生命和健康。从中药或天然药物中提取有效成分,研究其抗肿瘤作用或对某些抗肿瘤化学药物的增敏和抗耐药作用已成为当前医药学界关注的热点。多甲氧基黄酮是近年来发现的一类具有较强抗肿瘤活性的黄酮类成分。该文就多甲氧基黄酮类成分抗肿瘤作用及其机制的研究进展作一综述。Tumor is a disease with high mortality rate,which seriously threatens the human life and health. To study the antitumor effect,sensitization and anti-drug-resistant action of effective ingredients extracted from traditional Chinese medicine or natural medicine is a hotspot. Polymethoxyflavone is a class of flavonoids with strong anti-tumor activity found in recent years.In this paper,the research progress on anti-tumor action and its mechanisms of polymethoxyflavonoids is reviewed.

关 键 词：多甲氧基黄酮 肿瘤 橘红素 川陈皮素 甜橙黄酮 凋亡 自噬 

分 类 号：R284.1[医药卫生—中药学] R329.24[医药卫生—中医学]