木村病9例并文献复习  

Kimura disease: a report of 2 cases and review of literature

作　　者：王小娟 成洲[1] 贾晓宁 王晓萍[1] 

机构地区：[1]青岛大学附属烟台毓璜顶医院,山东烟台264000

出　　处：《全科口腔医学电子杂志》2017年第10期1-3,6,共4页Electronic Journal of General Stomatology

摘　　要：目的探讨总结我院9例Kimura病的临床表现、病理学特点及实验室检测,并结合相关文献对木村病诊断、鉴别诊断及治疗方法等进行相关讨论总结。方法回顾性分析我院9例就诊于口腔科、耳鼻咽喉头颈外科、血液科及肿瘤科的Kimura病患者的相关资料,并对其临床表现、实验室检测、病理结果、治疗方法及预后进行对比分析。结果 9例患者均为男性,平均发病年龄为45.7岁(范围为20岁至66岁)。从发病到手术的间隔从6个月到13年不等。随访时间3~15年,无死亡记录。5例腮腺病变、3例颈部病变、1例腋下病变。2例伴有皮肤瘙痒。2例复发。8例行手术治疗,术后行放疗。1例未行手术治疗,已进行6次化疗。临床表现均为病变区无痛性皮下肿胀、周界不清、质软、区域淋巴结肿大,病理学上表现为滤泡增生、血管增生和嗜酸性粒细胞浸润。实验室检查见外周血嗜酸性粒细胞升高,血清IgE明显升高。结论 Kimura病是一种少见的病因不明、无特异性临床表现的慢性疾病,主要发生于亚洲地区中年男性,通常表现为头颈部肿块,伴局部淋巴结病变,部分可累积唾液腺。主要依据临床表现、实验室检查及病理检查等作出诊断。Kimura病可通过手术切除或类固醇激素、局部放射治疗等方式控制肿物的生长及复发。Objective To investigate the clinical manifestations, pathological features and laboratory tests of 9 cases of Kimura＇s disease in our hospital, and to discuss and summarize the diagnosis, differential diagnosis and treatment of Kimura disease with related literature. Methods Retrospective analysis of 9 cases treated in the Department of Stomatology, Department of Otolaryngology Head and Neck surgery, related data in patients with Kimura disease in Department of Hematology and oncology, and its clinical manifestations, laboratory examination, pathology, treatment and prognosis were analyzed. Results 9 patients were male, the average age was 45.7 years （range 20 to 66 years old）. From the onset to surgery interval from 6 months to 13 years. The follow-up time ranged from 3 to 15 years, no death record.5 cases of parotid gland lesions, 3 cases of cervical lesions, 1 cases of axillary lesions. 2 patients with pruritus. 2 relapsed. 8 patients underwent surgical treatment, postoperative radiotherapy. 1 cases without surgical treatment, has 6 times of chemotherapy. The clinical manifestations were painless swelling of the skin lesion area, perimeter is not clear, soft, regional lymph nodes, pathology showed follicular hyperplasia, vascular hyperplasia and eosinophilia eosinophil in？ ltration. Laboratory examination on peripheral blood eosinophils increased, serum IgE increased signi？ cantly. Conclusion Kimura disease is a rare disease of unknown etiology, chronic nonspeci？ c clinical manifestations, mainly occurred in Asia in middle-aged men, usually for head and neck tumors, with local lymph node lesions, partial cumulative salivary gland. The main clinical features, laboratory examination and pathological examination to diagnosis of.Kimura disease by surgical resection or steroid hormone, growth and recurrence of local radiotherapy and control of tumor.

关 键 词：KIMURA病 嗜酸性粒细胞 血清IGE 

分 类 号：R597[医药卫生—内科学]