新福菌素注射剂联合奈达铂注射剂治疗局部晚期鼻咽癌的临床研究  

Clinical trial of actinomycin injection combined with nedaplatin injection in the treatment of locally advanced nasopharyngeal carcinoma

作　　者：李文全[1] 刑洪瑜 曹忠胜[1] 钱伟 

机构地区：[1]苏州大学附属第二医院耳鼻喉科,江苏苏州215000 [2]镇江第一人民医院耳鼻喉科,江苏镇江212002

出　　处：《中国临床药理学杂志》2017年第20期2016-2019,共4页The Chinese Journal of Clinical Pharmacology

基　　金：江苏省六大人才高峰基金资助项目(2011021);苏州市科技计划基金资助项目(SYS201233)

摘　　要：目的探讨联合新福菌素及奈达铂化疗在局部晚期鼻咽癌治疗中的应用价值,为临床更为有效的治疗局部晚期鼻咽癌提供参考。方法将80例局部晚期鼻咽癌患者随机分为对照组40例和试验组40例。2组患者均接受放疗治疗,放疗治疗方案应用调强适形放射治疗方案。对照组给予30 mg·m^(-2)奈达铂,静脉滴注,每周1次;试验组在对照组的基础上给予新福菌素注射剂0.4 mg+5%葡萄糖注射液500 m L,静脉滴注,伴行静脉输液4~5 h,每2 d用药1次。2组均治疗6周。比较2组患者的鼻咽部原发灶和颈部淋巴结转移灶的临床疗效以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为67.50%(27例/40例)和45.00%(18例/40例),差异有统计学意义(P<0.05)。治疗后,咽部原发病灶面积均下降,试验组和对照组分别为(19.11±2.07),(23.6±5.51)mm;颈部淋巴结转移分别为(5.49±3.92),(9.24±3.83)mm,差异有统计学意义(P<0.05)。试验组和对照组的药物不良反应有骨髓抑制、胃肠道反应、腔黏膜反应、口干反应、皮肤反应。试验组和对照组的药物不良反应发生率分别为82.50%(33例/40例)和72.50%(29例/40例),差异无统计学意义(P>0.05)。结论新福菌素联合奈达铂治疗局部晚期鼻咽癌方案临床疗效好,安全性高。Objective To explore the value of actinomycin combined with nedaplatin in the treatment of locally advanced nasopharyngeal carcino- ma, and provide a reference in clinical treatment of locally advanced na- sopharyngeal carcinoma. Methods A total of 80 patients with locally advanced nasopharyngeal carcinoma were randomly divided into control group （n -- 40 capes） and treatment group （ n -- 40 cases）. The control group was given nedaplatin 30 mg ·m-2 once a week by intravenous drip. The treatment group was given aetinomyein 0. 4 mg ＋ 5% GS 500 mL by deep intravenous fluids for 4 -5 h, one time two days, based on the control group. The clinical efficacy and adverse drug reactions of the primary nasopharyngeal and cervical lymph node metastases were com- pared between the two groups. Results After treatment, the total effec- tive rates in the treatment group and the control group were 67.50% （27 eases/40 cases） and 45.00% （ 18 cases/40 cases） , and the difference was statistically significant （P 〈0.05）. After treatment, the decreasedarea of primary lesion of pharynx in the treatment group and the control group were （19. 11 ＋2. 07）, （23.6 ＋5.51 ） mrm The area of neck lymph node metastasis in treatment group and control group were （5.49 ＋ 3.92 ）, （9. 24 ＋ 3.83 ） mm,the differences were statistically significant （ P 〈 0. 05 ）. The adverse drug reactions in the control group and the treatment group were myelosuppression, oral mucosal reaction, gastrointestinal reaction, dry mouth, skin reaction. The incidences of adverse drug reactions in the control group and the treatment group were 72. 50% （29 eases/40 cases） and 82. 50% （33 eases/40 cases） respectively, the difference was not statistically significant （P 〉 0. 05 ）. Conclusions In the treatment of locally advanced nasopharyngeal carcinoma, combined Aetinomycin with Nedaplatin can improve the clinical treatment effect while no significant difference between the incidence of adverse reactions ,the trea

关 键 词：新福菌素 奈达铂 鼻咽癌 

分 类 号：R979.1[医药卫生—药品]