粪便肿瘤型M2丙酮酸激酶在大肠腺瘤检测中的价值  

Value of fecal tumor M2 pyruvate kinase in colorectal adenoma detection

作　　者：张煜[1] 蒋元烨[1] 冯明丽[1] 王瑾萍 金磊[1] 曹勤[1] Zhang Yu Jiang Yuanye Feng Mingli Wang Jinping Jin Lei Cao Qin(Department of Gastroenterology, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, Chin)

机构地区：[1]上海中医药大学附属普陀医院消化内科,200062

出　　处：《中国综合临床》2017年第8期714-717,共4页Clinical Medicine of China

基　　金：上海中医药大学预算内项目（2016YSN60）;上海中医药大学附属普陀医院院级重点专科项目（2016103A）

摘　　要：目的 评价粪便肿瘤型M2丙酮酸激酶（M2-PK）在大肠腺瘤检测中的价值,了解其是否可作为大肠腺瘤检测的初筛工具.方法 应用酶联免疫吸附试验（ELISA）检测65例大肠腺瘤、25名对照者的粪便肿瘤型M2-PK值,同时在大肠腺瘤组中行外周血肿瘤标志物癌胚抗原（CEA）、糖链抗原（CA）19-9和CA24-2水平检测及粪便隐血试验检查.结果 大肠腺瘤组粪便肿瘤型M2-PK检测值（6.033±4.123）较对照组（2.782±1.464）U/ml增高,差异有统计学意义（t=-3.839,P=0.000）.腺瘤直径≥2 cm组检测值最高（8.775±6.548）U/ml,t=9.635,P=0.034,腺瘤直径越大,粪便肿瘤型M2-PK阳性率越高（85.7%与41.7%、29.6%,χ2=11.977,P=0.003）.大肠腺瘤组粪便肿瘤型M2-PK检测阳性率均高于外周血CEA、CA19-9和CA24-2以及粪便隐血试验（46.2%与6.2%、1.5%、1.5%、27.7%,χ2=76.607,P=0.000）.结论 粪便肿瘤型M2-PK对大肠腺瘤诊断有较好的临床价值.Objective To estimate the value of fecal tumor M2-PK in the detection of colorectal adenoma and to evaluate its potential as a screening tool for colorectal adenoma.Methods Enzyme-linked immunosorbent assay （ELISA） was used to detect the fecal tumor M2-PK in stool samples of 65 patients with colorectal adenoma and 25 controls.At the same time,the peripheral blood tumor markers such as carcinoembryonic antigen （CEA）,carbohydrate antigen （CA） 19-9,CA24-2 and fecal occult blood test （FOBT） were detected in the colorectal adenoma group.Results The detection value of fecal tumor M2-PK in the colorectal adenoma group showed a significant increase,compared with the control group（（6.033±4.123） U/ml vs.（2.782±1.464） U/ml,t=-3.839,P=0.000）.The highest detection value was found in the group where the diameter of adenoma was greater than or equal to 2 cm （（8.775±6.548） U/ml,t=9.635,P=0.034）.The larger the diameter of adenoma,the higher the positive rate of fecal tumor M2-PK （85.7% vs.41.7% vs.29.6%,χ2=11.977,P=0.003）.In the colorectal adenoma group,The positive detection rate of fecal tumor M2-PK was significantly higher than that of CEA,CA19-9,CA24-2 and FOBT （46.2% vs.6.2% vs.1.5% vs.1.5% vs.27.7%,？2=76.607,P=0.000）.Conclusion Fecal tumor M2 pyruvate kinase has a good clinical value in the diagnosis of colorectal adenoma.

关 键 词：粪便肿瘤型M2丙酮酸激酶 大肠腺瘤 诊断试验 

分 类 号：R735.34[医药卫生—肿瘤]