Noninvasive photoacoustic measurement of absorption coefficient using internal light irradiation of cylindrical diffusing fiber  

作　　者：彭东青 朱莉莉 李志芳 李晖 

机构地区：[1]School of Science Jimei University [2]Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education of China College of Photonic and Electronic Engineering Fujian Normal University

出　　处：《Optoelectronics Letters》2017年第5期367-371,共5页光电子快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.61675043 and 81571726);the Natural Science Foundation of Fujian Province(Nos.2015J01006 and 2017J01742);the Doctoral Scientific Research Foundation of Jimei University(No.ZQ2016005)

摘　　要：Absorption coefficient of biological tissue is an important parameter in biomedicine, but its determination remains a challenge. In this paper, we propose a method using focusing photoacoustic imaging technique and internal light irradiation of cylindrical diffusing fiber(CDF) to quantify the target optical absorption coefficient. Absorption coefficients for ink absorbers are firstly determined through photoacoustic and spectrophotometric measurements at the same excitation, which demonstrates the feasibility of this method. Also, the optical absorption coefficients of ink absorbers with several concentrations are measured. Finally, the two-dimensional scanning photoacoustic image is obtained. Optical absorption coefficient measurement and simultaneous photoacoustic imaging of absorber non-invasively are the typical characteristics of the method. This method can play a significant role for non-invasive determination of blood oxygen saturation, the absorption-based imaging and therapy.

关 键 词：Imaging techniques IRRADIATION Light absorption Photoacoustic effect 

分 类 号：R318[医药卫生—生物医学工程] TN253[医药卫生—基础医学]