T细胞介导的炎症反应在心肌纤维化中的“双刃剑”作用  

The double-edged sword role of T cell-mediated inflammatory reaction in myocardial fibrosis

作　　者：石亚男[1] 门素珍 孙孟华 刘巍[1] Shi Ya＇nan Men Suzhen Sun Menghua Lui Wei(Department of Internal Medicine Citical Diseases, the 1 st Affiliated Hospital of Harbin Medical University, Harbin 150010, China)

机构地区：[1]哈尔滨医科大学附属第一医院内科危重症科,150001

出　　处：《国际免疫学杂志》2017年第5期553-556,共4页International Journal of Immunology

基　　金：国家自然科学基金面上项目（81270310）;哈尔滨医科大学于维汉院士杰出青年基金（301000100005）、黑龙江省教育厅海外学人重点项目（1252HQ013）

摘　　要：心肌纤维化涉及到多种复杂的生物学机制。目前，对于免疫介导的心肌纤维化备受关注，而对于心肌损伤时T细胞介导的炎症反应在心肌纤维化中的作用尚存在争议。早期的炎症反应有利于心肌修复，但过度的炎症反应则促进纤维化发生。因此，详尽了解T细胞在心肌纤维化中的作用，有助于通过控制或干预过度的炎症反应来防治心肌纤维化发生，为心脏疾病提供新的治疗方法。Myocardial fibrosis involves a variety of complex biological mechanisms. At present, the im- mune-mediated myocardial fibrosis has attracted much attention. In the myocardial injury, T cell-mediated in- flammatory reaction in the role of myocardial fibrosis is still controversial. The early inflammatory reaction is conducive to myocardial repair,while excessive inflammation response can contribute to fibrosis. Therefore,un- derstanding the role of T cells in myocardial fibrosis may help us prevent myocardial fibrosis via controlling or intervening the excessive inflammatory response, and may provide new treatment for heart diseases.

关 键 词：T淋巴细胞 心肌纤维化 心室重构 炎症 

分 类 号：R542.23[医药卫生—心血管疾病]