醋氯芬酸与曲马多对经尿道前列腺电切术后膀胱痉挛性疼痛的疗效与安全性分析  

Efficacy and safety of aceclofenac and tramadol on bladder spastic pain after TURP

作　　者：胡春勇 梁荣杰 陈志健 陈增谋 

机构地区：[1]广西梧州市人民医院泌尿外科,广西梧州543000

出　　处：《国际泌尿系统杂志》2017年第5期729-731,共3页International Journal of Urology and Nephrology

摘　　要：目的 比较分析醋氯芬酸与曲马多对经尿道前列腺电切术（transurethral resection ofthe prostate,TURP）后患者膀胱痉挛性疼痛的疗效与安全性.方法 选择196例于本院泌尿外科就诊的前列腺增生患者作为研究对象,随机分为两组,每组98例,A组术后给予醋氯芬酸分散片;B组术后给予曲马多缓释片.比较两组患者术后24h内VAS评分、膀胱痉挛出现的次数与持续时间及药物不良反应发生情况.结果 两组患者术后24h内各时间节点的VAS评分、膀胱痉挛出现的次数与持续时间差异无统计学意义（P＞0.05）.B组患者恶心、眩晕、头痛、精神不振及发热等不良反应发生率明显高于A组（P＜0.05）.结论 醋氯芬酸与曲马多对经TURP术后患者膀胱痉挛性疼痛的疗效相当,醋氯芬酸的安全性相对较高.Objective To investigate the efficacy and safety of aceclofenac and tramadol on bladder spastic pain after TURP.Methods A total of 196 patients with prostatic hyperplasia in our hospital were chosen as study objects,and who were randomly divided into two groups,the patients in the group A received aceclofenac dispersible tables and the patients in the group B received tramadol sustainedrelease tablets after the TURP.The VAS pain score,frequency and duration of bladder spasm and the occurrence of adverse drug reactions were compared between the two groups in 24 hours after TURP.Results Within 24 hours after TURP,the VAS pain score of each time node,the frequency and duration of bladder spasm between the two groups had no statistical difference（P ＞ 0.05）.The incidence rate of adverse reactions such as nausea,dizziness,headache,lethargy and fever in group B was significantly higher than group A（P ＜ 0.05）.Conclusions Aceclofenac and tramadol have equivalent curative efficacy on bladder spastic pain after TURP and aceclofenac has better satety.

关 键 词：前列腺增生 经尿道前列腺切除术 电外科手术 疼痛 曲马朵 

分 类 号：R699[医药卫生—泌尿科学]