血清趋化因子的表达水平与其狼疮肾炎血浆吸附远期疗效的关系分析  

Relationship between serum chemokine expression level in lupus nephritis with long term curative effect of plasma purification

作　　者：朱兴华[1] 罗伟雄[1] 陈璐[1] 丘宝珍 黄东霞[1] 

机构地区：[1]梅州市人民医院血液净化中心,广东梅州514031

出　　处：《国际泌尿系统杂志》2017年第5期764-768,共5页International Journal of Urology and Nephrology

基　　金：梅州市科技计划项目（2014891）

摘　　要：目的 探讨狼疮肾炎血浆吸附的远期疗效及其与血清趋化因子水平的关系.方法 选取行血浆吸附治疗的狼疮肾炎患者32例为研究组,均随访至少2年,检测统计患者的24h尿蛋白定量水平及其2年复发率.另选取30例同期进行健康体检者为对照组.采用酶联免疫吸附法检测2组血清趋化因子5（CCL5）、巨噬细胞炎症蛋白1α（MIP-1oα）、巨噬细胞炎症蛋白1β（MIP-1β）等趋化因子水平并分析狼疮肾炎血浆吸附患者血清趋化因子水平与其24h尿蛋白定量水平的关系.比较复发和无复发患者的血清趋化因子水平并分析其血清趋化因子水平与其复发的关系及其预测其复发的价值.结果 与对照组比较,研究组治疗前的血清CCL5、MIP-1α、MIP-1β等趋化因子水平和24 h尿蛋白定量水平均升高（P＜0.05）.与治疗前比较,研究组治疗后和随访期间的血清趋化因子水平均降低（P＜0.05）.研究组随访2年复发率为68.75％（22/32）,且复发患者治疗前后和随访期间的血清趋化因子水平均高于无复发患者（P＜0.05）.狼疮肾炎血浆吸附患者血清CCL5、MIP-1 α、MIP-1β与其24 h尿蛋白定量水平及其复发均相关（P＜0.05）.且狼疮肾炎血浆吸附患者治疗前后血清趋化因子水平单独和联合预测其复发的价值良好,其中以治疗后血清趋化因子水平联合预测其复发的价值最佳.结论 血清趋化因子水平与狼疮肾炎血浆吸附远期疗效明显相关且对其复发的预测价值良好,可能作为其远期疗效评估的参考指标.Objective To explore the long curative effect of plasma purification treating lupus nephritis and its relationship with serum chemokine levels.Methods Thirty-two patients with lupus nephritis who underwent plasma adsorption treatment were selected as the research group at least 2years of follow-up.Two-year recurrence rate and 24 h urine protein quantitative level were statistically analyzed.Another 30 cases of healthy persons in the same period were selected as the control group.Enzyme-linked immunosorbent method was applied to detect serum chemokine 5 （CCL5）,macrophage inflammatory protein 1α（MIP-1α） macrophage inflammatory protein 1β（MIP-1β） and other chemokine levels in the 2 groups,and the relationship between serum chemokine levels with the 24 h urine protein quantitative level in patients with lupus nephritis was analyzed.Serum chemokine levels of patients with or without lupus nephritis recurrence were compared,and the relationship between serum chemokine level with its recurrence and the value of serum chemokine level predicting the recurrence were analyzed.Results Compared with control group,serum CCLS,MIP-lα,MIP-1βand other chemokine and 24 h urine protein quantitative level of the research group before treatment were elevated （P ＜ 0.05）.Compared with before treatment,serum chemokine level of the research group after treatment and during the follow-up period were lower （P ＜ 0.05）.Two-year follow-up recurrence rate of the research group was 68.75％,and before and after treatment and follow-up period serum chemokine levels of patients with lupus nephritis recurrence were higher than that of patients without lupus nephritis recurrence （P ＜ 0.05）.Serum CCL5,MIP-1α,MIP-1β of patients with lupus nephritis and had plasma adsorption treatment were closely related to the 24 h urine protein quantitative level and recurrence （P ＜ 0.05）.Value of before and after treatment serum chemokine levels of patients with lupus nephritis and had plasma adsorption treatment singly a

关 键 词：狼疮肾炎 趋化因子类 

分 类 号：R593.242[医药卫生—内科学]