Fabrication of a polypseudorotaxane nanoparticle with synergistic photodynamic and chemotherapy  

作　　者：Tao-Tao Xu Jun-Hua Li Fu-Rong Cheng Yi-Xin Zhang Jun Cao Wen-Xia Gao Bin He 

机构地区：[1]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China [2]School of Chemical Engineering. Sichuan University. Chengdu 610065, China [3]College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China

出　　处：《Chinese Chemical Letters》2017年第9期1885-1888,共4页中国化学快报（英文版）

基　　金：financial support of National Natural Science Foundation of China(No.51573111);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT-15R48)

摘　　要：A polypseudorotaxane（PPR） nanoparticle was fabricated by the self-assembly of m PEG-protoporphyrin IX（PpIX） conjugate and a-CDs via the host-guest interaction.The nanoparticle loaded with anticancer drug doxorubicin（DOX） exerted synergistic photodynamic and chemotherapy.The nanoparticle was spherical with the mean size of 89 nm,the low critical micelle concentration（CMC） of DOX-loaded nanoparticle was 9.3 mg/m L and the drug loading content was 9.93%.The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species（ROS）cytotoxicity and chemotherapeutic efficacy to cancer cells.The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.A polypseudorotaxane（PPR） nanoparticle was fabricated by the self-assembly of m PEG-protoporphyrin IX（PpIX） conjugate and a-CDs via the host-guest interaction.The nanoparticle loaded with anticancer drug doxorubicin（DOX） exerted synergistic photodynamic and chemotherapy.The nanoparticle was spherical with the mean size of 89 nm,the low critical micelle concentration（CMC） of DOX-loaded nanoparticle was 9.3 mg/m L and the drug loading content was 9.93%.The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species（ROS）cytotoxicity and chemotherapeutic efficacy to cancer cells.The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.

关 键 词：Polypseudorotaxane Protoporphyrin IX Photodynamic therapy ROS Chemotherapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]