吸烟对COPD和支气管哮喘患者FeNO表达的影响  

作　　者：周俊[1] 陶玉坚[1] 欧阳小平[1] 

机构地区：[1]江苏省扬州市第一人民医院,225009

出　　处：《浙江临床医学》2017年第11期2018-2020,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨吸烟对COPD和支气管哮喘患者呼出气一氧化氮（FeNO）表达的影响。方法85N患者根据临床病史及肺功能特点，分为慢性阻塞性肺病（COPD）组62例、哮喘组23例。健康体检者25例为对照组。然后根据吸烟情况将3组人群划分为吸烟者与不吸烟者。比较3组间FeNO值、肺功能指标，同时比较3组内吸烟与不吸烟者的FeNO值；将每组吸烟者的吸烟指数与FeNO值进行相关性分析。结果（1）哮喘组FeNO值明显高于COPD组与对照组[（35．3±8．9）vs（17．7±10．8）、（13．4±3．3），F=56．112，P〈0．05]，而COPD组与对照组FeN0值比较差异无统计学意义。（2）COPD组、哮喘组的1秒用力呼气量占预计值百分比（FEVI％）、1秒用力呼气量占用力肺活量的百分比（FEV1／FVC）均低于对照组，COPD组的FEV1／FVC显著低于哮喘组（P〈0．05），COPD组、哮喘组的FEV1％差异无统计学意义（P〉0．05）。（3）COPD组吸烟者FeNO值均明显低于不吸烟者（P〈0．05），哮喘组、对照组吸烟者与不吸烟者FeNO值差异无统计学意义（P〉0．05）。（4）COPD组吸烟指数与FeNO值呈明显负相关，其他组则无明显相关关系。结论吸烟可以导致COPD患者FeNO值明显降低，但对支气管哮喘患者的FeNO影响不大。Objective To discuss the influence of smoking on fractional exhaled nitric oxide （ FeNO ） expression in COPD patients and bronchial asthma patients. Methods 85 patients based on clinical history and lung function features were divided into chronic obstructive pulmonary disease （ COPD ） group （ 62 cases ） and asthma group （ 23 cases ） . The 25 cases of healthy people were selected as a control group. Then the three groups were divided into smokers and non-smokers according to smoking habit. The three groups FeNO values, lung function and FeNO values were compared in three groups of smokers and non-smokers.The correlation analysis smoking index and FeNO values of each group of smokers was conducted. Results （ 1 ） FeNO in asthma group was significantly higher than COPD group and the control group （ 35.3 ± 8.9 vs 17.7 ± 10.8, 13.4 ± 3.3, F=56.112, P〈0.05 ） , while the COPD group and control group was no difference between the value of FeNO significance. （ 2 ） COPD group, asthma group＇s second forced expiratory volume in percentage of predicted value （FEV1%） , the percentage of forced expiratory volume in one second forced vital capacity （ FEVI / FVC ） were lower than the control group, COPD group FEV1 / FVC was significantly lower than the asthmatic group （P〈0.05） , COPD group, FEVI% asthma group had no significant difference （P〉0.05） . （ 3 ） COPD, smokers FeNO values were significantly lower than non-smokers （ P〈0.05 ） , asthma group and control group of smokers and non-smokers FeNO was no significant difference （P〉0.05 ） . （ 4 ） COPD group smoking index and FeNO values correlated negatively, the other group had no significant correlation. Conclusion Smoking can cause FeNO values significantly lower in patients with COPD, but has little effect on FeNO patients with bronchial asthma.

关 键 词：吸烟 慢性气道炎症 慢性阻塞性肺病 支气管哮喘 呼出气一氧化氮 吸烟指数 

分 类 号：R511.6[医药卫生—内科学]