贵阳地区育龄人群HbA_2和HbF参考范围的研究  

Establishment of the Reference Range of HbA_2 and HbF in Guiyang Population of Reproductive Age

作　　者：韩文平 王树辉[3] 杨楠楠[1] 徐琴 韩媛媛 黄凌 黄盛文[3] 安邦权[3] HAN Wenping WANG Shuhui YANG Nannan XU Qin HAN Yuanyuan HUANG Ling HUANG Shengwen AN Bangquan(Department of Medical Laboratory , Guizhou Medical University, Guiyang 550004, Guizhou, China Department of Clinical Laboratory, the People~ Hospital of Guizhou, Guiyang 550002, Guizhou, China)

机构地区：[1]贵州医科大学医学检验学院,贵州贵阳550004 [2]贵州医科大学 [3]贵州省人民医院检验科,贵州贵阳550002

出　　处：《贵州医科大学学报》2017年第10期1117-1120,共4页Journal of Guizhou Medical University

基　　金：国家自然科学基金(81660023);贵州省科学技术厅基础计划[黔科合人才团队(2015)4019号];贵阳市科技创新平台计划[筑科合同(20161001)35]

摘　　要：目的:探讨贵阳地区育龄人群血红蛋白A2(HbA_2)和血红蛋白F(HbF)的参考范围。方法:采用毛细管电泳技术,对497例孕妇(正常孕妇组)、180例育龄期男性(正常男性组)和155例育龄期未孕女性(正常女性组)的血红蛋白进行测定,比较各组HbA_2和HbF的检测结果和参考范围。结果:整体HbA_2均值为(2.70±0.21)%,HbF中位数与四分位间距为0(0.3%),参考范围分别为2.3%~3.1%和<0.9%;正常男性组和正常孕妇组的HbA_2的平均值分别为(2.70±0.23)%和(2.70±0.19)%,显著高于正常女性组的(2.63±0.21)%(P<0.01),参考范围分别为2.3%~3.2%、2.3%~3.1%和2.2%~3.0%;正常男性组、正常女性组和正常孕妇组间的HbF分布差异有统计学意义(P<0.01),参考范围分别为<0.5%、<1.1%和<1.0%。结论:贵阳地区育龄人群的HbA_2和HbF数值受到性别及妊娠状态的影响。Objective： To establish the reference range of HbA2 and Hb F in Guiyang population of reproductive age. Methods： Hemoglobin analysis was performed in 497 pregnant women,180 men of reproductive age and 155 non-pregnant women of reproductive age by using capillary electrophoresis. The value and reference ranges of HbA2 and Hb F of different groups were compared. Results： On the whole,the mean value of HbA2 was（ 2. 70 ± 0. 21） %,the median value and interquartile range of Hb F were 0 and 0. 3%,and the reference ranges of HbA2 and Hb F were 2. 3% ^ 3. 1% less than0. 9% respectively. The mean values of HbA2 of normal men and normal pregnant women were（ 2. 70± 0. 23） % and（ 2. 70 ± 0. 19） % respectively,significantly higher than that of normal female（ 2. 63± 0. 21） %（ P〈0. 01）,with the reference ranges were 2. 3% ^ 3. 2%,2. 3% ^ 3. 1% and 2. 2% ^3. 0% respectively. The distributions of Hb F in normal male,normal female and normal pregnant women had statistical difference（ P〈0. 01）,with the reference ranges less than 0. 5%,1. 1% and1. 0% respectively. Conclusion： The reference ranges of HbA2 and Hb F in Guiyang population of reproductive age have been established. Both gender and pregnancy status have a certain effect on the reference range.

关 键 词：血红蛋白A2 血红蛋白F 参考值 性别因素 贵阳 

分 类 号：R556.7[医药卫生—血液循环系统疾病]