芪玄抑甲宁治疗甲亢的主要药效学研究  

Pharmacodynamic Research of Qixuan Yijianing in the Treatment of Hyperthyroidism

作　　者：刘树民 甄喆[1,2] 王可心 汪娜 张娜[1,2] 杨智明 柳长凤[2,3] LIU Shu -min ZHEN Zhe WANG Ke- xin WANG Na ZHANG Na YANG Zhi - ming LIU Chang - feng(Drug Safety Evaluation Center, Heilong, jiang Un.iversity of Chinese Medicine, Harbin. 150040, China Key Laboratory of Chinese Materia Medica（ Ministry of Education ）, Heilongjiang University of Chinese Medicine, Harbin 150040, China Research Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学药物安全性评价中心,黑龙江哈尔滨150040 [2]黑龙江中医药大学北药基础与应用研究教育部重点实验室,黑龙江哈尔滨150040 [3]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040

出　　处：《中医药学报》2017年第5期48-51,共4页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(81302898);黑龙江省教育厅科学技术研究项目(12541744);黑龙江省青年科学基金项目(QC2012C038)

摘　　要：目的:研究芪玄抑甲宁对甲亢的治疗作用。方法:检测芪玄抑甲宁各剂量组对甲亢大鼠外观行为及体质量、甲状腺激素水平以及组织病理学改变等指标的变化。结果:芪玄抑甲宁各剂量组能显著降低甲亢大鼠血清中三碘甲腺原氨酸(T3)、甲状腺素(T4)的水平并使促甲状腺激素(TSH)的水平升高,并且可以显著改善甲亢大鼠的组织病理样的变化。结论:芪玄抑甲宁对甲亢大鼠具有良好的治疗效果。Objectives： To study the eurative effect of Qixuan Yijianing on hyperthyroidism. Methods： The behaviour, weight, thyroid hormone level,.pathological changes of thyroid tissue were observed in hyperthyreosis rats with different doses of Qixuan Yijianing. Results： Qixuan Yijianing could significantly improve body weight in hyperthyroidism rats, reduee the serum levels of T3 and T4, increase TSH level, and improve Ihe morphology of thyruid tissue. Conclusion： Qixuan Yijianing has a guod therapeutic effect for hyperthyroidism.

关 键 词：芪玄抑甲宁 甲亢 药效学 

分 类 号：R285.5[医药卫生—中药学]