扩散加权成像在慢性血吸虫肝病中的应用价值  

The value of diffusion weighted imaging in chronic hepatic schistosomiasis

作　　者：张洪[1,2] 胡明秀 李长富[2] 王国光[2] 孔鹏 孟令平[2] 

机构地区：[1]泰山医学院研究生部,山东泰安271000 [2]上海市第六人民医院金山分院放射科,上海201500

出　　处：《医学影像学杂志》2017年第10期1933-1936,共4页Journal of Medical Imaging

基　　金：上海市卫生计生委面上项目(编号:201540242)

摘　　要：目的研究DWI不同b值的表观扩散系数(apparent diffusion coefficient,ADC)值、指数化表观扩散系数(exponential apparent diffusion coefficient,eADC)值、灌注ADC值、灌注eADC值在慢性血吸虫肝病中的应用价值。方法对经临床及病理证实的慢性血吸虫肝病患者35例和无肝病组38例行常规肝脏MR检查后,进行DWI扫描,设b值为0,50、600s/mm^2,测量肝ROI得到ADC值和eADC值,并计算出灌注ADC值和灌注eADC值,将其数据与病理结果进行对照分析。结果慢性血吸虫肝病组的ADC值及灌注ADC值较无肝病组低,而eADC值较无肝病组高,且均有统计学意义(P<0.01);慢性血吸虫肝病组灌注eADC值与无肝病组差异无统计学意义(P>0.05)。慢性血吸虫肝病组表现为不同程度的纤维组织增生和假小叶形成,均可见虫卵纤维化及钙化结节。结论扩散加权成像对诊断慢性血吸虫肝病有重要价值。Objective To evaluate the value of the apparent diffusion coefficient（ ADC）,exponential apparent diffusion coefficient（ eADC）,perfusion ADC（ ADCper） and perfusion eADC（ eADCper） of diffusion-weighted imaging（ DWI） with different parameter b in the chronic schistosomiasis liver disease. Methods 35 subjects confirmed as chronic hepatic schistosomiasis by clinical and pathologic methods and 38 subjects which had no liver disease were enrolled in the study. All of these subjects underwent by conventional MRI and then by DWI scan. The parameter b was set as 0,50,600 s/mm^2. The ROI of hepatic was measured to get theADC and eADC values,and then theADCper and eADCper values were colculated. These values were compared with the pathological results. Results Compared with the normal liver group,theADC and ADCper values of chronic hepatic schistosomiasis group were significantly lower,and the eADC value was significantly higher（ P〈 0. 01）. Whereas,the eADCper values had no significant difference of the two groups（ P〉 0. 05）. In the histopathology aspect,different degrees of the fibrous tissue proliferation and pseudo lobule formation were seen in the chronic hepatic schistosomiasis group,and every subject had visible fibrotic eggs and calcified nodules. Conclusion DWI is of great value in the diagnosis of chronic hepatic schistosomiasis.

关 键 词：血吸虫性 肝疾病 磁共振成像 扩散加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R383.2[医药卫生—诊断学]