血清TNF-α与Npt和G-CSF对胎膜早破合并羊膜腔感染的诊断分析  

Diagnostic of serum TNF-α,Npt and G-CSF in premature rupture of membrane and amniotic cavity infections

作　　者：周斌[1] 梁菁苹[1] 丁仁波[1] 王甜甜[1] 刘冬霞 郭书焕 车艳红[1] 

机构地区：[1]郑州市妇幼保健院产二病区,河南郑州450000

出　　处：《中华医院感染学杂志》2017年第19期4504-4506,4514,共4页Chinese Journal of Nosocomiology

摘　　要：目的探讨血清肿瘤坏死因子-α(TNF-α)、新喋呤(Npt)、粒细胞集落刺激因子(G-CSF)用于胎膜早破合并羊膜腔感染诊断的临床价值。方法 2013年6月-2016年5月期间的68例胎膜早破患者作为观察组,同期70例正常孕妇作为对照组,对比两组血清TNF-α、Npt、G-CSF水平;根据是否合并羊膜腔感染将68例胎膜早破患者分为羊膜腔感染组36例与非羊膜腔感染组32例,对比两组患者血清TNF-α、Npt、G-CSF水平;对比羊膜腔感染患者不同严重程度患者的血清TNF-α、Npt、G-CSF水平。结果观察组血清TNF-α、Npt、G-CSF水平分别为(776.82±89.61)ng/L、(16.91±4.11)mmol/L、(109.33±21.71),均显著高于对照组的(478.53±90.10)ng/L、(7.24±4.02)mmol/L、(82.32±21.67)(P<0.01);合并羊膜腔感染组血清TNF-α、Npt、G-CSF水平分别为(784.82±85.10)ng/L、(18.74±1.51)mmol/L、(115.36±22.01)显著高于无羊膜腔感染组(492.61±84.98)ng/L、(9.82±1.48)mmol/L、(93.22±21.89)(P<0.01);胎膜早破合并羊膜腔感染患者中,血清TNF-α、Npt、GCSF水平随羊膜腔感染程度的加重表现出显著增高趋势(P<0.01)。结论胎膜早破合并羊膜腔感染患者血清TNF-α、Npt、G-CSF水平明显增高,且随羊膜腔感染严重程度的加重而显著上升,可在一定程度上对胎膜早破合并羊膜腔感染起到有效的预测和早期诊断作用。OBJECTIVE To discuss the diagnostic value of serum TNF-α,Npt and G-CSF in premature rupture of membrane（PROM）and amniotic cavity infections.METHODS During Jun.2013 to May 2016,68 patients with PROM were selected as observation group and 70 normal pregnant women were selected as control group.The serum TNF-α,Npt and G-CSF were compared between the two groups.The 68 cases of premature rupture of membranes were divided into amniotic cavity infection group（36cases）and non amniotic cavity infection group（32cases）according to the amniotic cavity infections,the serum TNF-α,Npt and G-CSF between the two groups were compared,and serum TNF-α,Npt and G-CSF levels of patients with different severity of amniotic cavity infections were compared.RESULTS The serum TNF-α,Npt and G-CSF were（776.82±89.61）ng/L,（16.91±4.11）mmol/L and（109.33±21.71）in observation group,which were significantly higher than（478.53±90.10）ng/L,（7.24±4.02）mmol/L and（82.32±21.67）in control group（P〈0.01）.The serum TNF-α,Npt and G-CSF were（784.82±85.10）ng/L,（18.74±1.51）mmol/L and（115.36±22.01）in PROM patients with amniotic cavity infections,which were significantly higher than（492.61±84.98）ng/L,（9.82±1.48）mmol/L and（93.22±21.89）in PROM patients without amniotic cavity infections（P〈0.01）.The levels of serum TNF-α,Npt and G-CSF were significantly increased with the aggravation of amniotic cavity infection in PROM patients with amniotic cavity infections（P〈0.01）.CONCLUSIONSerum TNF-α,Npt and G-CSF are significantly higher in patients with PROM and amniotic cavity infections,which increased with the aggravation of amniotic cavity infections.Serum TNF-α,Npt and G-CSF play an effective role in the prediction and early diagnosis in a certain extent of PROM combined with amniotic cavity infections.

关 键 词：TNF-Α NPT G-CSF 胎膜早破 羊膜腔感染 

分 类 号：R714.433[医药卫生—妇产科学]