益气活血化瘀法治疗急性脑梗死后出血转化的临床疗效观察  

Clinical Observation on Yiqi Huoxue Huayu Therapy in the Treatment of Hemorrhagic Transformation after Acute Cerebral Infarction

作　　者：贾翔 

机构地区：[1]广东省广州市中西医结合医院,广州510800

出　　处：《中西医结合心脑血管病杂志》2017年第19期2466-2468,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察益气活血化瘀法治疗急性脑梗死后出血转化的临床疗效。方法按照随机原则选取符合标准的急性脑梗死病人29例,分为治疗组和对照组。比较两组基质金属蛋白酶-9(MMP-9)表达水平、美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数(BI)评分。结果治疗组在出血转化后7d、21d的MMP-9水平、NIHSS评分较发现出血转化当天均明显减低(P<0.05),治疗组与对照组在出血转化后7d、21d的MMP-9水平差异有统计学意义(P<0.05),出血转化21d的NIHSS评分差异有统计学意义(P<0.05),出血转化90d两组病人BI评分分布差异有统计学意义(P<0.05)。结论益气活血化瘀法对急性脑梗死后出血转化病人具有明显治疗作用,可明显降低病人MMP-9表达水平,并促进病人神经功能恢复,显著改善病人预后,提高生活能力。Objective To explore the efficacy and prognosis of Yiqi Huoxue Huayu method in the treatment of hemorrhagic transformation after acute cerebral infarction（ACI）.Methods According to the principle of random selection standards,twenty-nine patients with ACI were randomly divided into two groups：control group treated with routine treatment,and treatment group with Yiqi Huoxue Huayu method.The efficacy was evaluated.Matrix metallopeptidase 9（MMP-9）level was observed.National institute of Health Stroke Scale（NIHSS）and Barthel Index（BI）scores were evaluated.Results At the 7th day and 21st day,MMP-9 levels and NIHSS after treatment were significantly improved compared with those before the treatment in treatment groups（P〈0.05）.There was significant difference in the MMP-9 level at the 7th and 21th day after treatment,NIHSS scores at the 21st day after treatment,BI score distribution at the 90th day after treatment between two groups（P〈0.05）.Conclusion Yiqi Huoxue Huayu method can obviously reduce MMP-9 level,promote neurological recovery,improve the prognosis and ability of living in patients with hemorrhagic transformation after ACI.

关 键 词：急性脑梗死 出血转化 益气活血化瘀法 基质金属蛋白酶-9 神经功能 BARTHEL指数 中风 

分 类 号：R277.7[医药卫生—中医学]