盐酸替罗非班对STEMI患者心肌标志物水平及近期预后的影响  

Effects of tirofiban hydrochloride on myocardial markers and short-term prognosis in patients with STEMI

作　　者：李曼 

机构地区：[1]商丘市第一人民医院心内一科,河南商丘476100

出　　处：《中西医结合心血管病电子杂志》2017年第21期5-6,共2页Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察盐酸替罗非班对ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者心肌标志物水平及近期预后的影响。方法选择2016年4月至2017年1月商丘市第一人民医院收治的STEMI患者50例,随机分为对照组25例和试验组25例。对照组接受常规治疗,试验组在此基础上上加用盐酸替罗非班进行治疗。观察两组治疗效果。结果治疗后,对照组水肌酸激酶同工酶、肌钙蛋白平均高于试验组,差异有统计学意义(P<0.05);对照组心血管事件发生率高于试验组,两组不良反应发生率相当,差异无统计学意义(P>0.05)。结论在在STEMI患者中应用盐酸替罗非班治疗效果显著,可有效降低心肌标志物水平,减轻心肌损伤,可改善近期预后,且安全性较高。Objective To observe the effect of tirofban hydrochloride on myocardial markers and short-term prognosis in patients with ST-elevation elevation myocardial infarction（STEMI）.Methods Fifty patients with STEMI were randomly divided into control group （n=25） and experimental group （n=25）.The patients were randomly divided into control group（n=25）and trial group（n=20）.The control group received routine treatment,the test group on the basis of the addition of tirofban hydrochloride for treatment.Two groups of treatment were observed.Results The levels of creatine kinase isoenzyme and troponin in the control group were signifcantly higher than those in the control group（P〈0.05）.The incidence of cardiovascular events in the control group was higher than that in the control group The incidence was quite different, the difference was not statistically signifcant （P〉 0.05）.Conclusion The effect of tirofban hydrochloride in STEMI patients is signifcant,which can effectively reduce the level of myocardial markers,reduce myocardial injury,improve the prognosis and improve the safety.

关 键 词：盐酸替罗非班 心肌标志物 近期预后 

分 类 号：R541.4[医药卫生—心血管疾病]