自体富血小板凝胶与京万红软膏治疗糖尿病足溃疡的疗效比较  

Comparison of Curative Effect of Autologous Platelet Rich Gel and Jingwanhong Ointment in the Treatment of Diabetic Foot Ulcers

作　　者：黎小燕[1] 习燕华[1] 李毅[1] 张秋平[1] 钟树妹[1] 刘泽洪[1] 

机构地区：[1]江西省赣州市人民医院,江西赣州341000

出　　处：《中国医学创新》2017年第29期57-60,共4页Medical Innovation of China

基　　金：江西省赣州市科技计划项目(GZ2017ZSF192)

摘　　要：目的:研究并比较自体富血小板凝胶与京万红软膏治疗糖尿病足溃疡的临床疗效。方法:2017年2-9月在赣州市人民医院内分泌科糖尿病足住院患者中随机抽取50例糖尿病足溃疡患者作为研究对象,所有患者按照计算机随机数字分组法被分为自体富血小板凝胶组与京万红软膏组,每组25例。治疗8周后,比较两组患者的临床疗效、创面愈合时间、住院时间、住院费用、不良反应发生情况、创面肉芽形态评分、疼痛评分、瘙痒评分、生活质量评分。结果:自体富血小板凝胶组、京万红软膏组的总有效率分别为96.00%、92.00%,组间比较差异无统计学意义(P>0.05);自体富血小板凝胶组的创面愈合时间、住院时间均短于京万红软膏组(P<0.05),其住院费用少于京万红软膏组(P<0.05);治疗期间,两组患者均未发生药物相关不良反应;两组患者治疗后的创面肉芽形态评分、疼痛评分、瘙痒评分较治疗前均显著降低(P<0.05),而在治疗后,自体富血小板凝胶组的各项评分均低于京万红软膏组(P<0.05);治疗后,自体富血小板凝胶组的各项生活质量评分均高于京万红软膏组(P<0.05)。结论:糖尿病足溃疡患者采用自体富血小板凝胶、京万红软膏治疗均具有显著的临床疗效,但自体富血小板凝胶的疗效更优,可加快患者创面愈合,减轻创面疼痛和瘙痒,有利于提高患者生活质量水平。Objective：To study and compare the clinical efficacy of autologous platelet rich gel and Jingwanhong Ointment in the treatment of diabetic foot ulcer.Method：From February 2017 to September 2017 in the Department of Endocrinology of Ganzhou People＇s Hospital,50 cases of diabetic foot ulcer patients wereselected as the research objects.In accordance with the computer random number table method they were randomly divided into autologous platelet rich gel group and Jingwanhong Ointment group,25 patients in each group.After 8 weeks of treatment,clinical curative effect,wound healing time,hospitalization time,hospitalization costs,adverse reactions,wound granulation morphology score,pain score,pruritus score and life quality score of two groups were compared.Result：The total effective rate of autologous platelet rich gel group and Jingwanhong Ointment group were 96.00%,92.00%,there were no significant differences between two groups（P0.05）.The wound healing time and hospitalization time of autologous platelet rich gel group were shorter than those of Jingwanhong Ointment group（P0.05）,the hospital costs was less than that of Jingwanhong Ointment group（P0.05）.During treatment,there were no drug-related adverse reactions in two groups.After treatment,the granulation morphology score,pain score and pruritus score of two groups were significantly lower than those of before treatment（P0.05）,and the scores of self body of autologous platelet rich gel group were lower than those of Jingwanhong Ointment group（P0.05）.After treatment,the life quality score of autologous platelet rich gel group was higher than that of Jingwanhong Ointment group（ P0.05）.Conclusion：Diabetic foot ulcer treated with autologous platelet rich gel and Jingwanhong Ointment have significant clinical efficacy,but the curative effect of autologous platelet rich gel is better,can accelerate the wound healing,relieve pain and itching wound,is conducive to improve the quality of life of patients.

关 键 词：糖尿病足溃疡 自体富血小板凝胶 京万红软膏 

分 类 号：R587.2[医药卫生—内分泌]