住院患者质子泵抑制剂使用合理性分析  

Rational Usage of Proton Pump Inhibitors in Inpatients in a Hospital

作　　者：张拥军[1] 郭曙光[2] 方健[1] 张园[1] 彭伯坚[1] 

机构地区：[1]广东省广州市花都区人民医院,广东广州510800 [2]中山大学附属第三医院体检科,广东广州510630

出　　处：《中国药业》2017年第21期82-84,共3页China Pharmaceuticals

摘　　要：目的探讨住院患者质子泵抑制剂(PPIs)的使用情况,分析其不合理使用的原因,为临床合理用药提供参考。方法从医院信息管理系统随机抽取2017年1月至6月32个临床科室每月住院患者各10例,共1 920例,统计其PPIs的使用率,并进行分析。结果 1 920例住院患者中,PPIs的使用率为39.53%(759/1 920),预防使用率为67.98%(516/759),不合理使用率为39.00%(296/759);主要的不合理现象为无适应证用药,占不合理使用的67.23%(199/296)。结论 PPIs临床不合理使用率较高,普遍存在无适应证及过度使用现象,或使用时未能全面考虑到药物的溶剂、相互作用和禁忌证等因素。应强化PPIs不合理使用的干预手段,促进临床合理用药。Objective To investigate the usage of proton pump inhibitors（ PPIs） for inpatients, and analyze the reason of the irrational use of PPIs to provide reference for rational drugs use. Methods Ten inpatients used PPIs from 32 clinical departments separately were randomly chosen every month from January to June in 2017 from the hospital information management system,a total of 1 920 cases. The rate of use and the irrational use of PPIs were counted and their reasons were analyzed. Results In 1 920 cases, the rate of using PPIs was 39. 53%（ 759/1 920）, and the rate of preventive utilization of them was 67. 98%（ 516/759）, the rate of irrational use was39. 00%（ 296/759）. The main question was no indication that counted for 67. 23%（ 199/296） of all questions. Conclusion The irrational usage rate of PPIs is high. The phenomenon of no indication or over-use of PPIs is common,or the solvent,interaction and contraindication of drugs and other factors in the clinical use were not fully considered. Therefore,in order to improve the clinical rational drug use,the interventions for the clinical irrational use of PPIs should be strengthened.

关 键 词：质子泵抑制剂 合理用药 适应证 干预 

分 类 号：R969.3[医药卫生—药理学] R975[医药卫生—药学]