匹多莫德治疗小儿反复下呼吸道感染的用药效果评定  

Evaluation on Medication Effect of Pidotimod in Treatment of Children with Recurrent Lower Respiratory Tract Infection

作　　者：岳峰 

机构地区：[1]日照妇幼保健院儿科,山东日照276800

出　　处：《中外医疗》2017年第24期148-150,共3页China & Foreign Medical Treatment

摘　　要：目的研究匹多莫德治疗小儿反复下呼吸道感染的用药效果。方法方便选取2015年1月—2017年3月日照妇幼保健院小儿反复下呼吸道感染患儿92例,根据治疗方法分两组,常规治疗组进行常规治疗;匹多莫德组在常规治疗组基础上给予匹多莫德治疗。就两组患儿治疗前后IL-10、CD4+、免疫球蛋白E和反复下呼吸道感染控制率、药物不良反应发生率进行比较。结果匹多莫德组反复下呼吸道感染控制率明显高于常规治疗组(χ~2=6.243,P<0.05)。其中,常规治疗组总有效率69.57%;匹多莫德组总有效率93.48%。匹多莫德组药物不良反应发生率明显和常规治疗组差异无统计学意义(χ~2=0.523,P>0.05)。其中,匹多莫德组有1例出现口干,常规治疗组有1例出现恶心,发生率均为2.17%。治疗前两组患儿在IL-10、CD4+、免疫球蛋白E三项指标上相似(P>0.05)。匹多莫德组患儿治疗后CD4+、IL-10、免疫球蛋白E(38.43±6.25)%、(74.43±8.36)μg/L、(103.56±4.11)ng/L均明显优于常规治疗组(30.64±3.13)%、(65.42±7.48)μg/L、(158.46±9.13)ng/L(P<0.05)。结论匹多莫德治疗小儿反复下呼吸道感染的用药效果确切,可有效改善患儿临床症状,无明显不良反应,安全性高,值得推广应用。Objective To research the medication effect of pidotimod in treatment of children with recurrent lower respiratory tract infection. Methods 92 cases of children with recurrent lower respiratory tract infection in our hospital from January2015 to March 2017 were conveniently selected and divided into two groups according to the treatment method, the routine group adopted the routine treatment, while the pidotimod group adopted the pidotimod treatment on the basis of the routine treatment, and the IL-10,CD4+, Ig E, recurrent lower respiratory tract infection control rate and incidence rate of drug adverse reactions were compared between the two groups before and after treatment. Results The recurrent lower respiratory tract infection control rate in the pidotimod group was higher than that in the routine treatment group(χ~2=6.243, P<0.05),and the total effective rate in the routine treatment group and in the pidotimod group was respectively 69.57% and 93.48%,and there was no obvious difference in the incidence rate of drug adverse reactions between the two groups(χ~2=0.523, P>0.05), and there was 1 case with dry month in the pidotimod group,and in the routine treatment group, there was 1 case with nausea, and the incidence rate was 2.17%, before treatment, the IL-10,CD4+, Ig E of the three groups were similar(P>0.05), and the IL-10,CD4 +, Ig E in the pidotimod group were obviously better than those in the routine treatment group[(38.43±6.25)%,(74.43±8.36)μg/L,(103.56±4.11)ng/L vs(30.64±3.13)%,(65.42±7.48)μg/L,(158.46±9.13)ng/L](P<0.05).Conclusion The medication effect of pidotimod in treatment of children with recurrent lower respiratory tract infection is definite, which can effectively improve the clinical symptoms of children with high safety but without obvious side effect,which is worth promotion and application.

关 键 词：匹多莫德 小儿反复下呼吸道感染 用药效果 

分 类 号：R725.6[医药卫生—儿科]