自发性细菌性腹膜炎患者可溶性髓样细胞触发受体1表达研究  

Expression of Soluble Triggering Receptor Expressed on Myeloid Cell-1 in Spontaneous Bacterial Peritonitis

作　　者：张晓苹[1] 赵宏军[2] 马阿火[1] 秦月花[1] 孙爱静[3] 王晓丽[1] 王兴木[3] 

机构地区：[1]浙江省绍兴市人民医院消化内科,312000 [2]浙江省绍兴市人民医院神经内科,312000 [3]浙江省绍兴市人民医院中心实验室,312000

出　　处：《中国全科医学》2017年第14期1684-1688,共5页Chinese General Practice

基　　金：绍兴市科技局资助项目(2013B70078)

摘　　要：目的探讨可溶性髓样细胞触发受体1(sTREM-1)在自发性细菌性腹膜炎(SBP)患者中的表达情况。方法选取2013年6月—2014年12月绍兴市人民医院消化内科收治的肝硬化腹腔积液患者,23例并发SBP的患者为SBP组,66例未并发SBP的患者为非SBP组,SBP组患者根据病情分为轻症SBP(14例)和重症SBP(9例)。检测其血清白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、sTREM-1水平及腹腔积液细胞、多形核白细胞计数(PMN)、乳酸脱氢酶(LDH)、sTREM-1水平。结果 SBP组血清WBC、CRP、PCT、sTREM-1及腹腔积液细胞、PMN、LDH、sTREM-1水平均较非SBP组升高(P<0.05)。非SBP组腹腔积液培养均为阴性,SBP组细菌培养13例(56.5%)患者阳性。轻症及重症SBP患者血清WBC、CRP、PCT、sTREM-1及腹腔积液细胞、PMN、LDH、sTREM-1水平比较,差异均无统计学意义(P>0.05)。Pearson相关性分析显示,SBP组和非SBP组患者血清sTREM-1水平与腹腔积液sTREM-1水平呈正相关(r=0.737,P<0.001;r=0.275,P=0.025)。结论肝硬化腹腔积液并发SBP患者血清和腹腔积液sTREM-1水平升高,但是不同病情程度患者无差异,sTREM-1有可能作为诊断SBP的参考指标。Objective To investigate the expression of soluble triggering receptor expressed on myeloid cell - 1（sTREM-1） in spontaneous bacterial peritonitis （SBP）. Methods The participants enrolled in this study were 23 cirrhotic patients with ascites and SBP （ SBP group ）, and 66 cirrhotic patients with ascites but without SBP （ non - SBP group ）, admitted in Department of Gastroenterology,Shaoxing People＇s Hospital from June 2013 to December 2014. Based on the severity of SBP, patients in the SBP group were divided into mild SBP subgroup （14 cases） and severe SBP subgroup （9 c a se s） . White blood cells （ WBC） count, C - reactive protein （ CRP）, procalcitonin （PCT） and sTREM-1 in serum and exfoliated cells, polymorphonuclear leukocytes （PMN） count, lactate dehydrogenase （LDH） and sTREM-1 in ascitic fluid were measured in allthe patients. Results SBP group had higher WBC,CRP,PCT and sTREM - 1 in serum and exfoliated cells,PMN count,LDH and sTREM - 1 levels in ascitic fluid than non - SBP group did （ P 〈 0. 05 ） . Ascitic fluid bacterin all the patients in non - SBP group, but positive in 56. 5% （13/23） of the patients in SBP group. WBC, CRP, PCT and sTREM-1 in serum and exfoliated cells , PMN count , LDH and sTREM-1 levels in ascitic fluid did not differ significantly between mild SBP subgroup and severe SBP subgroup （P 〉 0. 05 ） . Pearson rank correlation coefficient analysis found that, serumsTREM-1 level was positively correlated with ascitic fluid sTREM-1 level in SBP group （r =0. 737 , P 〈0. 001 ） and non - SBP group （r=0. 275 , P =0. 025）. Conclusion The sTREM-1 levels elevated in both the serum and ascites in cirrhotic patients with ascites and SBP , and they did not vary with the severity of SBP. Ascitic and serum sTREMfor SBP.

关 键 词：腹膜炎 腹腔积液 可溶性髓样细胞触发受体1 

分 类 号：R656.41[医药卫生—外科学]