基于PI3K/Akt信号通路探讨中医药治疗冠心病的研究进展  

Research progress on intervention of traditional Chinese medicine on coronary heart disease through PI3K/Akt signaling pathway

作　　者：潘晔[1] 殷佳[1] 蔡雪朦 李琳[1] 徐一兰[1] 于春泉[1] 

机构地区：[1]天津中医药大学,天津300193

出　　处：《中草药》2017年第19期4100-4104,共5页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展计划("973")项目(2014CB542902)

摘　　要：磷酯酰肌醇-3激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase,PKB/Akt)信号通路可以调节细胞生长、代谢、凋亡等多种活动,具有广泛的生物学作用,参与肿瘤、冠心病、代谢紊乱等多种疾病的病理形成过程,是治疗这些疾病的重要靶点。近年来PI3K/Akt信号通路在冠心病发生发展中的作用日益受到重视,从PI3K/Akt的结构特点、与冠心病发生发展的关系及中药的干预作用3方面进行概述,以期为冠心病治疗药物的研发提供参考。Phosphoinositide 3-kinase（PI3 K）/protein kinase B（PKB/Akt） signaling pathway can regulate cell growth, metabolism, and apoptosis, which has a wide range of biological effects. It participates in the pathogenesis of various diseases such as cancer, coronary heart disease, and metabolic disorders, and it is an important target for treatment. In recent years, the role of PI3 K/Akt signaling pathway in the development of coronary heart disease has been increasingly paid attention. The relationship between the structural features of PI3 K/Akt and the development of coronary heart disease and the intervention of traditional Chinese medicine is summarized to provide a reference for the development of coronary heart disease treatment.

关 键 词：磷酯酰肌醇-3激酶 蛋白激酶B 冠心病 中医药 治疗靶点 

分 类 号：R285[医药卫生—中药学]