基于网络药理学的六经头痛片治疗偏头痛的作用机制探讨  

Study on mechanisms of Liujing Toutong Tablets in treatment of migraine by network pharmacology

作　　者：董亚楠 韩彦琪[2] 王磊[3] 许浚[2] 袁雪海 龚苏晓[2] 张洪兵[2] 朱晓丹[3] 张铁军[2] DONG Ya-nan HAN Yan-qiE WANG Lei XU Jun YUAN Xue-hai GONG Su-xiao ZHANG Hong-bing ZHU Xiao-dan ZHANG Tie-jun(Tianjin Medical University, Tianjin 300070, China Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Longshunrong Pharmaceutical Factory, Tianjin 300457, China)

机构地区：[1]天津医科大学,天津300070 [2]天津药物研究院,天津300193 [3]天津中新药业集团股份有限公司隆顺榕制药厂,天津300457

出　　处：《中草药》2017年第20期4174-4180,共7页Chinese Traditional and Herbal Drugs

摘　　要：目的对六经头痛片进行网络药理学研究,探究其治疗偏头痛的作用机制。方法选取六经头痛片中的18个入血及活性成分为研究对象,依据反向药效团匹配方法预测化合物的作用靶点,借助MAS 3.0生物分子功能软件及京都基因与基因组百科全书(KEGG)数据库获取相关通路并进行关联分析,最后利用Cytoscape软件构建六经头痛片"化合物-靶点-通路-疾病"的网络药理图。结果实验表明,18个化合物可通过72个作用靶标作用于88条通路,其中36个蛋白靶点和22条通路与偏头痛相关。结论六经头痛片可能通过干预与血管内稳态、炎症、神经中枢、免疫及激素调节等相关通路,起到疏风活络、利窍止痛的作用从而治疗偏头痛。Objective To study the mechanisms of Liujing Toutong Tablets（LTT） in the treatment of migraine by network pharmacology. Methods Eighteen components of LTT absorbed into blood were selected as the objects, and targets of compounds were predicted according to the reverse pharmacophore matching method. The related pathways and correlation analysis were explored by the MAS 3.0 biomolecule function software and the Kyoto Encyclopedia and Genomes（KEGG） database. Finally, the network of compound-target-pathway-disease of LTT was constructed by Cytoscape software. Results Eighteen compounds interacted with 88 pathways through 72 targets, of which 36 protein targets and 22 pathways were associated with migraine. Conclusion LTT may play a role in expelling wind and dredging collaterals, promoting orifice and pain-relieving by intervening with the related pathways of inflammation, homeostasis of blood vessels, nervous centralis, immunity, and hormonal regulation.

关 键 词：六经头痛片 偏头痛 网络药理学 作用机制 炎症 

分 类 号：R285.5[医药卫生—中药学]