粉团蔷薇根中1个新三萜苷  

A new triterpenic acid from roots of Rosa multiflora var. cathayensis

作　　者：李宇璐 代华年 马国需[3] 章文[3] 吴桐宇[3] 王云卿[1,3] 邹节明[4] 钟小清[4] 周艳林[4] 易蔚 许旭东[3] 袁经权[1,2] LI Yu-lu DAI Hua-nian MA Guo-xu ZHANG Wen WU Tong-yu WANG Yun-qing ZOU Jie-ming ZHONG Xiao-qing ZHOU Yan-lin YI Wei XU Xu-dong YUAN Jing-quan(Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, China School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, China Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China Guilin Sanjin Pharmaceutical Company Ltd., Guilin 541004, China)

机构地区：[1]广西药用植物研究所,广西南宁530023 [2]广西中医药大学药学院,广西南宁530001 [3]中国医学科学院药用植物研究所,北京100193 [4]桂林三金药业股份有限公司,广西桂林541004

出　　处：《中草药》2017年第20期4208-4214,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目"壮药金樱根新颖五环三萜抗炎活性成分及效应关系的研究"(81360683);广西中药药效研究重点实验室开放项目(14-045-12)

摘　　要：目的研究粉团蔷薇Rosa multiflora var.cathayensis根的化学成分。方法采用硅胶、HPLC等柱色谱方法进行分离纯化,并根据化合物的理化性质和光谱分析进行结构鉴定。结果从粉团蔷薇根的醋酸乙酯及二氯甲烷提取部位中分离得到了9个三萜类化合物,分别鉴定为粉团蔷薇甲苷(1)、阿江榄仁尼酸(2)、1β-羟基蔷薇酸(3)、阿江榄仁亭(4)、构莓苷F_1(5)、蔷薇酸(6)、委陵菜酸(7)、千花木酸(8)、野蔷薇苷(9)。结论化合物1为新化合物,命名为粉团蔷薇甲苷;所有化合物均为首次从粉团蔷薇根中分离得到。Objective To study the chemical from the roots of Rosa multiflora var. cathayensis. Methods The silica gel column chromatography was used to separate the chemical constituents from the roots of Rosa multiflora var. cathayensis. HPLC was used to analyze its purity, chemical and spectroscopy methods were used to determine their structures. Results Nine constituents were isolated and identified as multifloside A（1）, arjunic acid（2）, 1β-hydroxyeuscaphic acid（3）, arjunetin（4）, kaji-ichigoside F1（5）, euscaphic acid（6）, tormentic acid（7）, myrianthic acid（8）, and rosamultin（9）. Conclusion Compound 1 is a new compound named multifloside A; All compounds are obtained from the genus Rosa for the first time.

关 键 词：粉团蔷薇 三萜类 粉团蔷薇甲苷 阿江榄仁尼酸 1β-羟基蔷薇酸 阿江榄仁亭 

分 类 号：R284.1[医药卫生—中药学]