连钱草化学成分研究  

Chemical constituents of Glechoma longituba

作　　者：舒任庚 蔡慧 王晓敏 邓慧云 屠鹏飞[3] SHU Ren-geng CAI Hui WANG Xiao-min DENG Hui-yun TU Peng-fei(School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China Nanchang Jisheng Pharmaceutical Factory, Nanchang 330115, China School of Pharmacy, Peking University, Beijing 100083, China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]南昌济生制药厂,江西南昌330115 [3]北京大学药学院,北京100083

出　　处：《中草药》2017年第20期4215-4218,共4页Chinese Traditional and Herbal Drugs

基　　金：江西省科技支撑计划项目(2010BSA17600);国家自然科学基金资助项目(81360631)

摘　　要：目的研究连钱草Glechoma longituba全草的化学成分。方法采用有机溶剂提取,硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC及重结晶等方法进行分离纯化,通过理化性质和波谱数据鉴定化合物的结构。结果从连钱草75%乙醇中分离得到13个化合物,分别鉴定为熊果酸(1)、齐墩果酸(2)、原儿茶醛(3)、白桦脂酸(4)、木犀草素(5)、β-谷甾醇(6)、芦丁(7)、丁香酸(8)、乙酰丁香酸(9)、2,5-二甲氧基对苯二甲酸(10)、(E)-3-[4-(carboxymethoxy)-3-methoxyphenyl]acrylic acid(11)、大黄素(12)、黑麦交酯(13)。结论化合物8~10、12为首次从该植物中分离得到,化合物11、13为首次从活血丹属植物中分离得到。Objective To study the chemical constituents of Glechoma longituba. Methods Chemical constituents were extracted by organic solvents, isolated and purified by chromatographic techniques with silica gel, Sephadex LH-20, semi-preparative HPLC, and recrystallization. Their structures were elucidated on the basis of physiochemical and spectral analyses. Results Thirteen compounds were obtained and elucidated as ursolic acid（1）, asoleanolic acid（2）, protocatechualdehyde（3）, betulic acid（4）, luteolin（5）, β-sitosterol（6）, lutin（7）, syringic acid（8）, 4-acetoxy-3,5-dimethoxybenzoicacid（9）, 2,5-dihydroxy-1,4-benzenedicarboxylic acid（10）,（E）-3-[4-（carboxymethoxy）-3-methoxyphenyl] acrylic acid（11）, emodin（12）, and loliolide（13）. Conclusion Compounds 8—10 and 12 are isolated from this plant for the first time. Compounds 11 and 13 are isolated from the plants of Glechoma Linn. for the first time.

关 键 词：连钱草 熊果酸 丁香酸 大黄素 黑麦交酯 

分 类 号：R284.1[医药卫生—中药学]