疏肝活血方对血管性痴呆大鼠学习记忆的影响  

Effect of Shugan Huoxue Prescription on Learning and Memory in Vascular Dementia Rats

作　　者：陈维[1] 潘博希[2] 冯妮[1] 尹瑞文 

机构地区：[1]云南中医学院临床医学院,云南昆明650500 [2]云南省中医医院,云南昆明650021

出　　处：《云南中医中药杂志》2017年第10期79-81,共3页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：云南省应用基础研究自筹项目资助(NO:2013FZ085)

摘　　要：目的研究疏肝活血方对血管性痴呆(VD)大鼠学习记忆的影响。方法采用改进的2VO法制备VD大鼠模型。雄性SD大鼠90只,随机分为模型组、假手术组、多奈哌齐组、疏肝活血方高、中、低剂量组,每组15只。于造模3 d后开始灌胃给药,每天1次,连续4周。给药后4周行水迷宫实验进行行为学测试。结果疏肝活血方中剂量组大鼠学习记忆成绩明显高于模型组大鼠,差异有统计学意义(P<0.05)。结论疏肝活血方能提高血管性痴呆大鼠的学习记忆能力。Objective ： To study the effect of Shugan Huoxue Prescription on learning and memory in vascular dementia （VD） rats. Methods ： VD rat model was prepared by modified 2VO method. 90 male SD rats were randomly divided into a model group, a sham operation group, a donepezil group and Shugan Huoxue Decoction groups of high, medium and low dose, 15 rats each group. Three days after modeling, the rats were given oral administration, once a day for 4 weeks. Four weeks after administration, water maze test was conducted for behavioral testing. Results ： The learning and memory scores of Shugan Huoxue Decoction groups were significantly higher than those of the model group and the difference was statistically significant （ P 〈 0.05 ）. Conclusion： Shugan Huoxue Prescription can improve the learning and memory ability of vascular dementia rats.

关 键 词：疏肝活血方 血管性痴呆大鼠 学习记忆 水迷宫 

分 类 号：R285.5[医药卫生—中药学]