病原菌耐药性与抗菌药物使用量的相关性分析  

Correlation analysis of bacterial resistance and the antibiotic usage

作　　者：王晓坤[1] 黄新刚[1] 丁菊英[1] WANG Xiao-kun HUANG Xin-gang DING Ju-ying(Shengli Oil field Central Hospital, Dongying, Shandong 257034, Chin)

机构地区：[1]胜利油田中心医院药学部,山东东营257034

出　　处：《中华医院感染学杂志》2017年第20期4576-4580,共5页Chinese Journal of Nosocomiology

摘　　要：目的探讨细菌耐药情况与抗菌药物使用量之间的相关性。方法统计2010年1月-2016年12月医院病原菌耐药情况和抗菌药物使用频度(DDDs),采用Pearson相关性分析法考察细菌耐药率与抗菌药物DDDs之间的相关性。结果 2010-2016年,医院抗菌药物DDDs居前三位的均为头孢菌素类、大环内酯类和喹诺酮类;常见革兰阴性菌为大肠埃希菌和肺炎克雷伯菌,其中大肠埃希菌的耐药率与头孢吡肟、阿米卡星的DDDs呈正相关(P<0.05);常见革兰阳性菌为金黄色葡萄球菌和凝固酶阴性葡萄球菌,其中金黄色葡萄球菌的耐药率与克林霉素的DDDs呈正相关(P<0.05)。结论细菌耐药率与抗菌药物DDDs存在一定的相关性,科学、合理的使用抗菌药物可有效地降低细菌耐药率。OBJECTIVE To investigate and analyze the correlation of bacterial resistance and the antibiotic usage.METHODS The bacterial resistance and defined daily doses（DDDs）in our hospital from Jan.2010 to Dec.2016 were analyzed,and the correlation between them was analyzed by Pearson method.RESULTS From 2010 to 2016,the top 3 antibacterial agents DDDs in our hospital were cehpalosporins,macrolides and quinolones.The common gram-negative bacteria was Escherichia coli and Klebsiella pneumoniae,and the resistant rate of E.coli showed a positive correlation with the DDDs of cefepime and amikacin（P〈0.05）.The common gram-positive bacteria was Staphylococcus aureus and coagulase-negative Staphylococcus,and the resistant rate of S.aureus showed a positive correlation with the DDDs of clindamycin（P〈0.05）.CONCLUSION The bacterial resistant rate is correlated with the antibiotic DDDs,and the rational use of antibiotics can reduce the bacterial resistant rate.

关 键 词：抗菌药物 耐药率 相关性 使用频度 

分 类 号：R378[医药卫生—病原生物学]