慢性丙型肝炎感染患者多项生化指标动态监测研究  

Dynamic monitoring of multiple biochemical indexes in patients with chronic hepatitis C infection

作　　者：陈兴国[1] 杨静[1] 李庆欣[1] 李英[1] 尹林峰 刘伟 CHEN Xing-guo YANG Jing LI Qing-xin LI Ying YIN Lin-feng LIU Wei(Tianjin Taida Hospital, Tianjin 300457, Chin)

机构地区：[1]天津市泰达医院检验科,天津300457 [2]天津市塘沽传染病医院检验科,天津300457

出　　处：《中华医院感染学杂志》2017年第20期4592-4594,4598,共4页Chinese Journal of Nosocomiology

摘　　要：目的探讨慢性丙型肝炎感染患者多项生化指标动态监测特性。方法选择2012年12月-2014年12月医院收治的慢性丙型肝炎感染患者80例,根据患者慢性丙型肝炎感染中血清病毒载量的多少,分为高复制组36例和低复制组44例,对两组的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、胆碱酯酶(CHE)等多项生化指标进行检测,并分析两组患者不同阶段的HCV-RNA、抗-HCV阳性检测率。结果两组治疗前ALT、AST、CHE差异无统计学意义;治疗后2年高复制组ALT、AST分别为(75.21±12.38)U/L、(52.35±12.84)U/L高于低复制组(61.22±18.57)U/L、(31.32±8.64)U/L,差异均有统计学意义(P均<0.05);治疗后高复制组CHE为(2867.48±123.56)U/L显著低于低复制组(3564.12±211.45)U/L(P<0.05)。80例慢性丙型肝炎患者治疗前后不同阶段的HCV-RNA阳性率比较,均有统计学差异(P均<0.05)。结论慢性丙型肝炎感染患者,一旦发生感染,抗-HCV指标会长时间的呈现阳性,而HCV-RNA水平会随着患者病情的发展而变化,其越高对患者的肝功能损伤越严重。OBJECTIVE To investigate dynamic monitoring features of multiple biochemical indexes in patients with chronic hepatitis C infection.METHODS A total of 80 cases of patients with chronic hepatitis C infection in our hospital from Dec.2012 to Dec.2014 were randomly selected as the study objects.Based on the number of serum viral load of chronic hepatitis C infection,they were divided into high replication group（36 cases）and low replication group（44 cases）.A number of biochemical indexes including ALT,AST and CHE of patients were detected and analyzed,and the HCV-RNA and anti-HCV positive detection rates at the different stages of the patients were analyzed.RESULTS There was no significant difference in ALT,AST and CHE between the two groups before treatment.After treatment,the ALT and AST of high replication group were（75.21 ± 12.38）U/L and（52.35 ± 12.84）U/L,which were higher than（61.22±18.57）U/L and（31.32±8.64）U/L of low replication group,and the differences were significant（P〈0.05）.The CHE of high replication group was（2867.48 ±123.56）U/L,which was significantly lower than（3564.12±211.45）U/L of low replication group（P〈0.05）.The positive rates of HCV-RNA of the 80 cases of patients with chronic hepatitis C at different stages before and after treatment were significantly different（P〈0.05）.CONCLUSION In patients with chronic hepatitis C infection,once the infection occurs,the anti-HCV indexes will be positive for a long time,and HCV-RNA level which change with the development of the patient＇s condition,the higher the more severe of its function in patients with liver damage.

关 键 词：慢性丙型肝炎感染 生化指标 动态监测 

分 类 号：R512.63[医药卫生—内科学]