非高密度脂蛋白胆固醇水平与冠心病病情的相关性分析  

Correlation analysis between non-high density lipoprotein cholesterol and coronary heart disease

作　　者：杨永娜 刘杰 郝东云[3] 王志军 刘宁 邢彩耐 黄宇玲 YANG Yong-Na LIU Jie HAO Dong-Yun WANG Zhi-Jun LIU Ning XING Cai-Nai HUANG Yu-Ling(Second Department of Cardiovascular, Affiliated Hospital of Noah China University of Science and Technology, Tangshan, Hebei 063000, China Department of Emergency, Hospital of Kaiping District, Tangshan, Hebei 063021, Chi- na Department of Medicine, Hospital of Nanbao Development District, Tangshan , Hebei 063300, China)

机构地区：[1]华北理工大学附属医院心内二科,河北省唐山市063000 [2]唐山市开平区医院急诊科,河北省唐山市063021 [3]唐山市南堡开发区医院内科,河北省唐山市063300

出　　处：《中国动脉硬化杂志》2017年第10期1031-1035,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨非高密度脂蛋白胆固醇水平与冠心病患者病情的相关性。方法对522例行冠状动脉造影检查的患者进行回顾性分析,根据冠状动脉造影结果结合临床特点、心电图表现、心肌标志物结果分为非冠心病组、心绞痛组、心肌梗死组,平均年龄60.00±10.02岁。采用Gensini评分评估冠心病患者冠状动脉病变程度,收集所有患者临床资料,采集静脉血检测血脂指标并计算非高密度脂蛋白胆固醇值,分析非高密度脂蛋白胆固醇水平与冠心病病情的相关性。结果三组间的非高密度脂蛋白胆固醇水平、Gensini积分差异有统计学意义(P<0.05);心绞痛组非高密度脂蛋白胆固醇水平与Gensini积分正相关(r=0.130,P=0.022),心肌梗死组非高密度脂蛋白胆固醇水平与Gensini积分正相关(r=0.213,P=0.048);多元无序Logistic回归分析显示,年龄、性别、非高密度脂蛋白胆固醇水平是影响冠心病病情的危险因素(P<0.05)。结论非高密度脂蛋白胆固醇水平是影响冠心病患者病情的一项重要指标。Aim To investigate the correlation between non-high density lipoprotein cholesterol level and severity coronary heart disease（CHD）. Methods 522 cases of coronary angiography were retrospectively analyzed, according to the results of coronary angiography combined with clinical features, electrocardiogram and myocardial enzyme, which were divided into non-CHD group, angina pectoris group, myocardial infarction group. The average age is 60.00＋10.02 years. Gensini score was used to evaluate the degree of coronary artery lesions in patients with coronary heart disease, the clinical data of all patients were collected, and the serum lipid levels were measured and non-high density lipoprotein cho- lesterol was calculated. The correlation between non-high density lipoprotein cholesterol and coronary heart disease was analyzed. Results Gensini levels had statistically significant differences in the three groups （P〈 0.05） ; In angina pectoris group, non-high density lipoprotein cholesterol level and Gensini score are positively correlated （r=0. 130, P = 0.022） ; In myocardial infarction group, non-high density lipoprotein cholesterol level and Gensini score are positively cor- related （r=0. 213, P = 0.048） ; Logistic regression analysis showed that age, gender and non high density lipoprotein cho- lesterol level were risk factors for coronary heart disease （P〈0.05）. Conclusion Non-high density lipoprotein choles- terol is an important index to reflect the condition of patients with coronary heart disease.

关 键 词：非高密度脂蛋白胆固醇 冠心痛 冠状动脉造影 GENSINI积分 

分 类 号：R541[医药卫生—心血管疾病]