绝经后女性单核细胞/高密度脂蛋白胆固醇与冠状动脉SYNTAX评分的关系  

The relationship between monocyte to high-density lipoprotein cholesterol ratio and SYNTAX score of postmenopausal women with coronary atherosclerotic heart diseases

作　　者：王莹[1] 郑海生[1] 陈平[1] 马贵洲[1] 蔡志雄[1] 李智业[2] 郭海森[1] 王文亮[1] WANG Ying ZHENG Hai-Sheng CHEN Ping MA Gui-Zhou CAI Zhi-Xiong LI Zhi-Ye GUO Hai-Sen WANG Wen-Liang(Department of Cardiovasology, Shantou Central Hospital, Shantou, Guangdong 515031, China Intensive Care Unit, Shantou Central Hospital, Shantou , Guangdong 515031, China)

机构地区：[1]汕头市中心医院心血管内科,广东省汕头市515031 [2]汕头市中心医院重症监护室,广东省汕头市515031

出　　处：《中国动脉硬化杂志》2017年第10期1036-1040,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨绝经后女性单核细胞/高密度脂蛋白胆固醇比值(MHR)与冠状动脉SYNTAX评分的相关性。方法入组接受冠状动脉造影术确诊为冠状动脉粥样硬化性心脏病(冠心病)的绝经后女性180例,根据MHR(以第33和第66百分位点为截点)分为三组:低MHR组:MHR<0.28(n=59);中MHR组:0.28≤MHR≤0.43(n=61);高MHR组:MHR>0.43(n=60)。比较三组SYNTAX评分差异,采用Spearman相关性分析和多重线性回归分析MHR与SYNTAX评分的关系。结果高MHR组的SYNTAX评分(25±13)高于低MHR组(18±13)和中MHR组(19±12)(P=0.003)。高MHR组的白细胞计数、中性粒细胞计数、血清C反应蛋白水平均高于低MHR组和中MHR组(P<0.001)。Spearman相关分析表明MHR与SYNTAX评分相关(r=0.263,P<0.001)。多因素线性回归分析结果提示SYNTAX评分受MHR的影响,冠状动脉病变严重程度与MHR密切相关(F=4.777,P=0.031)。结论绝经后女性冠心病患者MHR与冠状动脉SYNTAX评分呈正相关,可预测冠状动脉病变的严重程度。Aim To investigate the relation between monocyte to high-density lipoprotein cholesterol ratio （MHR） and SYNTAX score in postmenopausal women with coronary atherosclerotic heart diseases （CAD）. Methods A cohort of 180 postmenopausM women was enrolled in this study, who was diagnosed as CAD by coronary angiography. The patients were categorized in three groups based on the admission MHR level： low MHR group（ MHR〈0.28, n = 59）, moderate MHR group（0.28≤MHR≤0.43, n=61）, high MHR group（MHR〉0.43,n=60）. Spearman correlation and multiple linear regression were used to describe the linear association between MHR and SYNTAX score. Results The SYNTAX scores of high MHR group （25±13） were higher than low MHR group （18±13） and moderate MHR group （ 19± 12） （P=0.003）. The counts of white blood cells, counts of neutrophil and serum levels of C-reactive protein in high MHR group were higher than those in low MHR group and moderate MHR group （ P 〈 0. 001 for all comparisons）. Spearman correlation analysis showed MHR was correlated with SYNTAX score（ r= 0.263 ,P〈0.001 ）. The result of multi- pie linear regression indicated that SYNTAX score was affected by MHR （F = 4.777, P = 0.031 ）. Conclusion This study demonstrated that MHR of postmenopausal women with CAD was significantly positively correlated with SYNTAX score. MHR may be used to predict coronary artery lesion of postmenopausal women with CAD.

关 键 词：绝经后女性 单核细肜高密度脂蛋白胆固醇 SYNTAX评分 冠状动脉粥样硬化性心脏病 

分 类 号：R5[医药卫生—内科学]