血浆低密度脂蛋白和高密度脂蛋白亚组分的临床意义及检测研究进展  

Advances in clinical significance and detection research of plasma low density lipoprotein and high density lipoprotein subunits

作　　者：米春芳 刘庆平[1] MI Chun-Fang LIU Qing-Ping(Key Laboratory of Carbohydrate and Lipid Metabolism Research of Liaoning Province ＆ College of Life Science and Technol- ogy, Dalian University, Dalian , Liaoning 116622, China)

机构地区：[1]辽宁省糖脂代谢研究重点实验室大连大学生命科学与技术学院,辽宁省大连市116622

出　　处：《中国动脉硬化杂志》2017年第10期1054-1060,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(81270361;81673494)

摘　　要：血浆低密度脂蛋白(LDL)和高密度脂蛋白(HDL)是临床心血管疾病(CVD)的重要生物化学指标。一些脂代谢异常疾病如肥胖、糖尿病、高血压和高脂血症尤其是动脉粥样硬化等都是CVD的危险因素,许多新的研究证明这些疾病患者的血浆LDL和HDL亚组分存在异常,其临床意义大于LDL和HDL总体异常。血浆LDL和HDL异常亚组分作为CVD临床检测指标已引起了广泛研究与关注。本文旨在对血浆LDL和HDL亚组分的临床意义及检测研究进展加以论述。Plasma low density lipoprotein （LDL） and high density lipoprotein （HDL） are important biochemical indicators of clinical cardiovascular disease （CVD）. Some disorders of lipid metabolism, such as obesity, diabetes melli- tus, hypertension and hyperlipidemia, especially atherosclerosis, are risk factors for CVD. Many new studies have demon- strated abnormalities of plasma LDL and HDL subunits in patients with these diseases, and their clinical significance is greater than the overall abnormalities of LDL and I4DL. Abnormal subunits of plasma LDL and HDL have been extensively studied and paid attention to as a clinical indicator of CVD. The purpose of this paper is to discuss the advances in clinical significance and detection research of plasma LDL and HDL subunits.

关 键 词：低密度脂蛋白 高密度脂蛋白 亚组分 脂代谢异常 心血管疾病 

分 类 号：Q513.5[生物学—生物化学]