壮药制剂棒柄花叶清肝胶囊的质量控制研究  

Studies on Quality Control Standards of Zhuang Medicine Bangbinghuaye Qinggan Jiaonang

作　　者：张颖 刘元 宋志钊 文志云 韦韡 ZHANG Ying LIU Yuan SONG Zhizhao WEN Zhiyun WEI Wei(Guangxi Institute for Chinese Medicine ＆ Pharmaceutical Science, Nanning 530022, China Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning 530022, China)

机构地区：[1]广西壮族自治区中医药研究院,广西南宁530022 [2]广西中药质量标准研究重点实验室,广西南宁530022

出　　处：《中国民族民间医药》2017年第20期38-41,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:制定壮药制剂棒柄花叶清肝胶囊的质量控制方法。方法:采用TLC法对制剂中虎杖和黄芪进行鉴别;采用HPLC法测定方中虎杖苷含量。结果:在虎杖薄层色谱中,壮药制剂棒柄花叶清肝胶囊与大黄素对照品,大黄素甲醚对照品色谱相应的位置上,斑点清晰,阴性无干扰,可作为定性鉴别;在黄芪薄层色谱图中,壮药制剂棒柄花叶清肝胶囊在与黄芪对照药材色谱相应的位置上,斑点清晰,阴性无干扰,可作为定性鉴别;HPLC测定虎杖苷在5.1~163.2μg范围内与峰面积性关系良好(r=0.999 8),平均回收率为98.8%,RSD为1.64%(n=6)。结论:建立的质量标准可控制壮药制剂棒柄花叶清肝胶囊的质量。Objective To set up studies on quality control standards of Zhuang Medicine Bangbinghuaye qinggan jiaonang. Meth- otis Polygonum Cuspidatum and Astragalus membranaceus were identified by TLC. The content of Polydatin was determined by HPLC. Results TLC spots of Polygonum Cuspidatum and Astragalus membranaceus were clear and negative without interference, which can be used as qualitative method. The calibration curves were linear in the range of 5.1 - 163.2μg for Polydatin r = 0. 9998, average recov- ery of Bergenin was 98.8%, RSD was 1.64% （ n = 6）. Conclusion The quality of Zhuang Medicine Bangbinghuaye qinggan jiaonang was effectively controlled by these quality standards.

关 键 词：壮药制剂 大黄素 大黄素甲醚 黄芪 虎杖苷 

分 类 号：R29[医药卫生—民族医学]