特发性肺纤维化患者幽门螺杆菌感染的流行病学分析  

Epidemiological analysis of helicobacter pylori infection in patients with idiopathic pulmonary fibrosis

作　　者：朱孟德[1] 张春美[1] 

机构地区：[1]合肥市第一人民医院呼吸内科,安徽合肥230001

出　　处：《安徽卫生职业技术学院学报》2017年第5期53-54,56,共3页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:探讨特发性肺纤维化(IPF)患者幽门螺杆菌(Hp)感染的流行病学及与病情的关系。方法:纳入某医院呼吸科收治的IPF患者80例、按年龄性别严格配对的健康体检者160例,采用胃食管反流量表(GerdQ)及病例调查表调查方式收集病史信息,进行进行常规化验、肺功能检测和13C尿素呼气试验。结果:IPF患者FEV1%、FVC%、DLCO%显著低于健康对照组,GerdQ评分和Hp阳性率显著高于健康组。IPF患者中,13C呼气试验阳性者与对照组13C呼气试验阳性者相比,性别、年龄、FEV1%、FVC%、DLCO%、GerdQ评分和肺纤维化评分的差异均无统计学意义。结论:IPF患者的Hp阳性率和胃食管反流评分高于正常人群组,但与肺功能和影像学严重程度无关。Objective：To study the patients with idiopathic pulmonary fibrosis（IPF） epidemiology of helicobacter pylori（Hp） infection and the relationship with the disease. Method： Include respiratory treated 80 cases of patients with IPF, by age, gender strictly matched healthy physical examination of 160 cases, adopt the stomach esophagus reverse flow meter（Gerd Q） and case history questionnaire way to collect information, conduct routine tests, pulmonary function testing, and 13 C urea breath test. Result： FEV1% and FVC%, DLCO % IPF patients significantly lower than that of healthy controls, Gerd Q scores and Hp positive rate was significantly higher than that of healthy group. In patients with IPF, 13 C breath test was compared with the control group of 13 C breath test positive for gender, age, FEV1% and FVC%, DLCO%, Gerd Q scores and pulmonary fibrosis score differences had no statistical significance. Conclusion： Hp positive rate of patients with IPF and gastroesophageal reflux score higher than the normal group, but has nothing to do with lung function and radiographic severity.

关 键 词：幽门螺杆菌 特发性肺间质纤维化 肺功能 胃食管反流 

分 类 号：R563.1[医药卫生—呼吸系统]