维生素D与不孕女性卵巢储备标志物的相关性分析  

Correlation analysis between vitamin D and ovarian reserve markers in infertile women

作　　者：孙丽君[1] 冯营营[1] 胡继君[1] 赵贝[1] 张俊韦 李哲[1] 

机构地区：[1]郑州大学第三附属医院生殖医学中心,450052

出　　处：《中华生殖与避孕杂志》2017年第9期706-710,共5页Chinese Journal of Reproduction and Contraception

摘　　要：目的探讨血清维生素D水平与卵巢储备标志物抗苗勒管激素(anti-Müllerian hormone,AMH)和窦卵泡数(antral follicle count,AFC)之间的关系。方法回顾性分析2016年5月—2017年6月第一次接受辅助生殖助孕技术治疗的不孕症患者共2 391例,根据患者血清25(OH)D_3水平分为≤30 nmol/L组(A组,n=417)、30.1~49.9 nmol/L组(B组,n=626)和≥50 nmol/L组(C组,n=1 348)。分析患者血清25(OH)D_3水平与不孕女性卵巢储备标志物血清AMH水平和AFC之间的相关性。结果 (1)各组患者间的年龄、体质量指数(BMI)、基础FSH、不孕原因构成比及不同季节的维生素D水平的差异均无统计学意义(P>0.05);(2)3组患者的AMH水平分别为(4.07±3.53)ng/mL、(4.12±3.43)ng/mL和(4.10±3.18)ng/mL;AFC分别为14.0±6.7、13.7±5.9和14.1±6.1,组间差异均无统计学意义(P>0.05);(3)调整潜在的混杂因素后,运用相关因素多重线性回归分析显示,血清AMH水平的偏回归系数(B)=-0.005,标准误差(sx)=0.007,P=0.506;AFC的B=-0.122,sx=0.019,P=0.214,与血清25(OH)D_3水平之间均无相关性(P>0.05)。结论不孕女性维生素D和卵巢储备标志物血清AMH水平及AFC之间不存在相关性,对维生素D缺乏的不孕女性通过补充维生素D以改善卵巢储备功能可能没有作用。Objective To investigate the relationship between serum vitamin D levels and ovarian reserve markers anti-Müllerian hormone（AMH） or antral follicle count（AFC）. Methods Totally 2 391 cases infertility patients who received assisted reproductive technology for the first time were retrospectively analysed.According to the serum 25（OH）D3 level, they were divided into ≤30 nmol/L group（group A, n=417）, 30.1-49.9 nmol/L group（group B, n=626）, ≥50 nmol/L group（group C, n=1 348）. The relationship were analysed between serum 25（OH）D3 levels and AMH or AFC among the above three groups. Results 1） There was no significant difference in age, BMI, basic FSH, infertility cause and vitamin D level in different seasons among the three groups（P〉0.05）. 2） There was no significant difference in AMH mean level [（4.07±3.53） ng/mL,（4.12±3.43） ng/mL and（4.10±3.18） ng/mL,respectively] and AFC（14.0±6.7, 13.7±5.9 and 14.1±6.1, respectively） among the three groups（P〉0.05）.3） After adjusting the potential confounding factors, we used the multivariate linear regression analysis and found that there was no correlation between AMH（B=-0.005, sx=0.007, P=0.506） or AFC（B=-0.122, sx=0.019, P=0.214）and serum 25（OH）D3 level（P〉0.05）. Conclusion There was no correlation between serum vitamin D and ovarian reserve marker AMH or AFC for infertile women. For infertile women lacking vitamin D, it may have no effects on improving ovarian reserve function by supplementing vitamin D.

关 键 词：维生素D 卵巢储备标志物 抗苗勒管激素(AMH) 窦卵泡数(AFC) 

分 类 号：R711.6[医药卫生—妇产科学] R714.8[医药卫生—临床医学]