溶血磷脂酸在卵母细胞体外成熟过程中作用的研究进展  

Research progress on the roles of lysophosphatidic acid in invitro maturation of oocytes

作　　者：邢雅欣 解其贵[2] 杨志勇 王玲[2] 千日成 

机构地区：[1]南通大学医学院,226000 [2]上海市第十人民医院生殖医学中心,200072

出　　处：《中华生殖与避孕杂志》2017年第9期759-762,共4页Chinese Journal of Reproduction and Contraception

基　　金：南通大学研究生科研创新计划资助项目(YKC16074);国家重点研发计划(2017YFC1001601)~~

摘　　要：卵母细胞体外成熟(IVM)已成为一项热门的辅助生殖技术(ART),有广泛的应用和发展前景。但其体外成熟率和受精后的发育能力还有待提高,培养条件需要进一步优化。溶血磷脂酸(LPA)是磷脂激素家族的重要成员,有生长因子和激素样活性,可产生广泛的生物学效应。研究表明LPA存在于卵泡液中,对卵泡发育、卵母细胞IVM、受精、胚胎发育、种植等产生重要作用。本文就LPA特性及其在卵母细胞体外成熟过程中的作用做一简要的阐述。In vitro maturation（IVM） of oocytes has become a popular assisted reproductive technology（ART）, which has broad application and development prospects. However, the maturation rate and developmental competence of those oocytes need to be improved. The most commonly used IVM culture conditions are still unsatisfied. Lysophosphatidic acid（LPA）, which has growth factor-like and hormone-like activities, is an important member of the phospholipid autacoid family. LPA can produce a wide range of biological effects. Studies have shown that LPA exists in follicular fluid, which has an important effect on follicular development and oocytes maturation,subsequent fertilization, embryo development and implantation. This article briefly reviews the characteristics of LPA and its role in IVM of oocytes.

关 键 词：溶血磷脂酸(LPA) 卵母细胞 体外成熟(IVM) 

分 类 号：R714.8[医药卫生—妇产科学]