茶螺烷的合成方法改进  

An Improvement on the Synthesis of Theasiprane

作　　者：刘长辉 丁双超 张哲 LIU Changhui DING Shuangchao ZHANG Zhe(College of Materials and Chemical Engineering, Huan Provincial Key Lab of Dark Tea and Jin-hua, Hunan City University, Yiyang, Hunan 413000, China The Fourth Highsehool ofTaojiang, Taojiang, Hunan 413000, China)

机构地区：[1]湖南城市学院材料与化学工程学院黑茶金花湖南省重点实验室,湖南益阳413000 [2]湖南省桃江县第四中学,湖南桃江413000

出　　处：《湖南城市学院学报（自然科学版）》2017年第4期71-73,共3页Journal of Hunan City University:Natural Science

基　　金：国家自然科学基金项目(21675042);湖南省教育厅优秀青年项目(15B043);黑茶金花湖南省重点实验室开放基金项目(HC6120)

摘　　要：本文以α-紫罗兰酮为原料,经间氯过氧苯甲酸环氧化、甲醇钠开环、连二亚硫酸钠还原碳碳双键,硼氢化钠还原羰基及脱水等5步反应合成了茶螺烷,产物结构经IR、1H-NMR和MS确证﹒通过改进生产工艺,总收率可达59.4%﹒In this paper, theasiprane was synthesized from a-ionone via epoxidation by metachloroperbenzoic acid, ring opening by sodium methoxide, reduction of carbon-carbon double bond by sodium dithionite, reduction of carboxide by sodium borohydride, and intramolecular cyclodehydration with an overall yield of approximate 59.4%. The structures were characterized by IR, 1H-NMR and MS.

关 键 词：茶螺烷 α-紫罗兰酮 连二亚硫酸钠 4 5-环氧-α-紫罗兰酮 二氢-β-紫罗兰酮 

分 类 号：O622.4[理学—有机化学]