高三酰甘油者血清2-己基-环丙烷辛酸甲酯变化及分析  

Clinical Significance of Serum Level of Cyclopropaneoctanoic Acid 2-Hexyl in Patients with Hypertriglyceridemia-Related Disorders

作　　者：艾文婷[1] 杜洁[2] 陈新军[3] 姜保周[3] 李秀红[1] 

机构地区：[1]陕西省人民医院心内科,西安710068 [2]陕西省人民医院体检中心,西安710068 [3]陕西省人民医院急诊科,西安710068

出　　处：《现代检验医学杂志》2017年第5期19-23,共5页Journal of Modern Laboratory Medicine

摘　　要：目的观察高三酰甘油相关疾病患者血清2-己基-环丙烷辛酸甲酯(CPOA2H)水平变化并探讨其临床意义。方法选取2013年3月～2015年12月陕西省人民医院收治的临床资料完整的单纯肥胖症女性患者53例(肥胖组)、肥胖症经3个月低卡路里食物饮食者62例(肥胖低卡路里饮食组)、慢性肾病患者46例(慢性肾病组)、健康体检者60例(对照组)气相色谱-质谱法(GC-MS)检测血清脂肪酸和CPOA2H含量。结果四组年龄、体重指数(BMI)、C反应蛋白(CRP)、总胆固醇(TC)、总三酰甘油(TAG)差异具有统计学意义(F=6.85～25.36,均P<0.05);肥胖组多数饱和脂肪酸(14:0,1:0)和单不饱和脂肪酸(14:1,16:1,18:1,20:1)均显著高于对照组(F=3.251～7.351,P<0.05);慢性肾病组多不饱和脂肪酸(18:2n-6,20:4n-6)显著低于对照组(F=4.351～6.251,P<0.05);四组血清CPOA2H水平差异具有统计学意义(F=19.95,P=0.005);对照组(r=0.63,P=0.033)和慢性肾病组(r=0.61,P=0.044)血清CPOA2H浓度与TAG相关,肥胖组和肥胖低卡路里饮食组血清CPOA2H浓度与TC(r=0.70,P=0.011;r=0.48,P=0.021),TAG呈正相关=0.75,P=0.024;r=0.72,P=0.018)。结论高三酰甘油的肥胖症和慢性肾病患者血清CPOA2H升高,血清CPOA2与TAG正相关,与BMI无关。Objective To observe the serum level of cyclopropaneoctanoic acid 2-hexyl （CPOA2H） in patients with hypertri- lyceridemia-related disorders,and investigate its clinical significance. Methods 53 obese patients （Obese group）, 62 obese patients after a 3 month low calorie diet （Obese patients after low calorie diet group） ,46 patients with chronic kidney disease （CKD group） ,and 60 healthy controls （Control group） were collected from Mar 2013 to Dec 2015 in shaanxi Provincial Peo- ple＇s Hospital. Gas chromatography-mass spectrometry （GC-MS） were used to detect the Serum fatty acid and CPOA2H level in four groups. Results Ages, body mass index （BMI）, C-reaction protein （CRP）, total cholesterol （TC）, triacytglycerols （TAG） among four groups had significant difference （F= 6.85-25.36 ,P〈0.05）. Most saturated fatty acid （14 ： 0,16 ： 0） and monounsaturated fatty acid （14 ： 1,16 ： 1,18 ： 1,20 ： 1） in obese group were higher than controls （F= 3. 251 7. 351 ,P〈0.05）. The polyunsaturated fatty acid （18 ： 2n-6,20： 4n-6） in CKD group were lower than controls （F=4. 351 -6. 251,P〈0.05）. There existed significant difference of serum levels of CPOA2H among four group （F = 19.95, P = 0. 005）. Serum level of CPOA2H in control （r=0.63,P=0. 033）and CKD group （r=0.61,P=0. 044） were positively re-ated with TAG. Serum level of CPOA2H in obese group and obese patients after low calorie diet group were positively related with TC （r=0. 70,P=0. 011 r=0. 48,P=-0. 021） and TAG （r=0. 75,P=0. 024;r=0.72,P=0. 018）. Conclusion Hypertrilyceridcmia-related disorders, such as obesity and CKD, presented with elevated serum levels of CPOA2H, it suggested that serum level of CPOA2H is positively related to serum TAG concentration rather than BMI.

关 键 词：高三酰甘油 2-己基-环丙烷辛酸甲酯 肥胖症 慢性肾病 

分 类 号：R589.2[医药卫生—内分泌] R446.112[医药卫生—内科学]