多囊卵巢综合征患者血清IL-23水平的检测及临床意义  

Clinical Significance of Serum IL-23 Levels in Patients with Polycystic Ovary Syndrome(PCOS)

作　　者：李丽春[1] 张红莉[1] 南刚[1] 

机构地区：[1]延安大学附属医院产科一病区,陕西延安716000

出　　处：《现代检验医学杂志》2017年第5期108-109,114,共3页Journal of Modern Laboratory Medicine

摘　　要：目的血清IL-23表达水平在多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者中的检测及其临床意义。方法选取在延安大学附属医院就诊的50例PCOS患者为观察组,同时选取50例健康女性为正常对照组。采用生化分析仪检测血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)的水平;血细胞计数仪检测白细胞(white blood cell,WBC)的含量;ELISA法检测血清IL-23的表达水平。结果观察组患者血清WBC水平分别为8 056.1±2 473.6mm^3,显著高于对照组的6 286.2±1071.4 mm^3,差异有统计学意义(t=4.642,P<0.001),而hs-CRP在两组则无明显差异(观察组为4.2±3.7mg/L,对照组为3.9±3.2 mg/L,t=0.434,P=0.665);PCOS患者血清IL-23水平为59.6±40.1pg/ml,显著高于健康女性人群(29.7±20.5 pg/ml),差异有统计学意义(t=4.695,P<0.001);PCOS患者血清IL-23诊断的最佳cutoff值为31.05 pg/ml,其中敏感度74.0%,特异度62.0%,AUC值0.729(95%CI范围0.630～0.827,P<0.001)。结论 PCOS患者血清IL-23水平显著上升,两者呈显著的正相关,可作为PCOS诊断的生物标志物之一。Objective To investigate and detect serum IL-23 levels in patients with PCOS. Methods A total of 50 PCOS pa tients in the Affiliated Hospital of Yan＇an University as the observed group and 50 healthy women as control group were studied in this research. Serum levels of high sensitivity C reactive protein （hs-CRP） were measured through biochemical an alyzer;White blood cell （WBC） was measured through automatic blood cell counter; The expression of serum IL-23 were measured by ELISA. Results Serum WBC levels were significantly higher in observed group than those in control group （8 056.1±2 473.6 mm^3 and 6 286.2 ±1071.4 mm^3 ,t=4. 642,P〈0. 001）. Besides,serum hs-CRP in two groups were no significant difference （observed group 4.2±3.7 mg/L and control group 3.9±3.2 mg/I.,t--O. 434 ,P=0. 665）. Furthermore, compared with control group, serum IL-23 levels were significantly higher in observed group and there was significant difference between the two groups （59.6±40. 1 pg/ml and 29.7±20.5 pg/ml,t=4. 695,P〈0. 001）. The best cutoff value for serum IL 23 concentration to diagnose PCOS was 31.05 pg/ml （sensitivity 74.0% ,specificity 62.0% ,and AUC 0. 729,95% CI：0. 630±0. 827,P%0. 001）. Conclusion Women with PCOS had higher serum IL-23 levels and there were significantly positive correlated. IL-23 could be a biomarker for PCOS diagnosis.

关 键 词：IL-23 多囊卵巢综合征 慢性炎症 

分 类 号：R711.75[医药卫生—妇产科学] R392.11[医药卫生—临床医学]