2型糖尿病患者颈动脉内-中膜厚度与血清IL-6和Fetuin-A水平的关系研究  

Study on the Relationship of Carotid Intimal-Medial Wall Thickness and the Expression of IL-6 and Fetuin-A in the Serum of Two Type Diabetes

作　　者：刘小玲[1] 李卫国[1] 李振华[1] 

机构地区：[1]新疆喀什地区第一人民医院干部病房,新疆喀什844000

出　　处：《现代检验医学杂志》2017年第5期115-117,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨白细胞介素6(IL-6)和胎球蛋白A(Fetuin-A)水平与2型糖尿病患者颈动脉内-中膜厚度的关系。方法选取2型糖尿病患者80例为试验组,健康体检者60例为对照组,通过酶联免疫吸附法检测研究对象血清IL-6和Fetuin-A水平,应用颈动脉多普勒彩色超声检查颈动脉内-中膜厚度(intimal-medial wall thickness,IMT)。结果 2型糖尿病患者血清IL-6水平明显高于对照组,Fetuin-A水平明显低于对照组(t=8.34～15.65,均P<0.05)。颈动脉内-中膜厚度正常者(A组,20例)IL-6水平为2.24±0.21 pg/L,Fetuin-A水平为5.41±0.32 ng/ml;内膜增厚患者(B组,18例)IL-6水平为3.44±0.18 pg/L,Fetuin-A水平为3.86±0.42 ng/ml;斑块形成患者(C组,22例)IL-6水平为4.95±0.31 pg/L,Fetuin-A水平为2.41±0.32 ng/ml;管腔狭窄患者斑块组(D组,20例)IL-6水平为5.35±0.31 pg/L,Fetuin-A水平为2.02±0.08 ng/ml。四组IL-6和Fetuin-A水平差异均有统计学意义(F=8.69～11.02,均P<0.05)。其中A组～D组IL-6水平逐渐升高,组间差异均有统计学意义(t=5.32～9.01,均P<0.05)。而Fetuin-A水平逐渐降低,组间差异也有统计学意义(t=6.14～11.53,均P<0.05)。结论 IL-6和Fetuin-A水平与2型糖尿病患者内-中膜厚度有关,可预见2型糖尿病患者有无动脉粥样硬化。Objective To investigate the relationship of carotid intimal-medial wall thickness（IMT） and the expression of IL- 6 and Fetuin-A in two type diabetes. Methods 80 patients with two type diabetes were chosen,and 60 cases healthypeople of examination for the control group. The levels of IL-6 and Fetuin-A were measured, and measured the intimal-medial thickness （IMT） of internal carotid artery by,carotid duplex ultrasonography scanning simultaneously, Results The level of IL-6 was significantly higher in two type diabetes than those in control group,and the level of Fetuin-A was declind （t~ 8.34 15.65,all P〈0.05）. IL-6 level in normal IMT （A group,20 cases） was 2.24±0.21 pg/L,Fetuin revel was 5.41±0.32 ng/ ml. IL-6 level in abnormal IMT （B group,18 cases） was 3.44±0.18 mm,and Fetuin level was 3.86±0.42 ng/ml. Relatively,IL-6 level in tMT with plaque （C group,22 cases） was 4.95±0.31 ng/ml,Fetuin-A level was 2.41±0.32 ng/ml. IL-6 level in lumen narrow （13 group, 20 cases） was 5.35± 0.31 ng/ml, and Fetuin-A level was 2.02±0. 08 ng/ml. There were obvious differences for four groups to detect IL-6 was Fetuin-A levels （F=8.69- 11.02, all P〈0. 05）. The level of IL-6 were rised little by little from A group to D group. There were obvious differences for comparison among groups （t： 5.32- 9.01, all P〈0.05）. The level of Fetuin-A were declined little by little from A group to I3 group,there were obvious differnce for comparison among groups （t：6.14-11.53,all P〈0. 05）. Conclusion There was a close correlation between IL-6 ,Fe- tuin-A level and carotid intimal-medial wall thickness（IMT） in two type diabetes. To detection IL-6 and Fetuin-A levels is a target to distinguish two type diabetes whether or not with atherosclerosis.

关 键 词：内-中膜厚度 白细胞介素6(IL-6) 胎球蛋白A 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌] R392.11[医药卫生—内科学]